Acknowledgements

Relevant works generated from the authors' laboratory were supported by the Research Grants Council of Hong Kong (HKUST 6096/98M and 2/99C).

References

Arshavsky VY and Bownds MD (1992). Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP. Nature 357, 416-7. Asano T, Morishita R, Ueda H, and Kato K (1999). Selective association of G protein ß4 with y5 and yi2 subunits in bovine tissues. J Biol Chem 274, 21 425-9. Bae H, Anderson K, Flood LA, Skiba NP, Hamm HE, and Graber SG (1997). Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interactions. J Biol Chem 272, 32 071-7. Baek KJ, Kang S, Damron D, and Im M (2001). Phospholipase C81 is a guanine nucleotide exchanging factor for transglutaminase II (Gah). and promotes a1B-adrenoreceptor-mediated GTP binding and intracellular calcium release. J Biol Chem 276, 5591-7. Bence K, Ma W, Kozasa T, and Huang XY (1997). Direct stimulation of Bruton's tyrosine kinase by

Gq-protein a-subunit. Nature 389, 296-9. Berestetskaya YV, FaureMP, Ichijo H, and Voyno-Yasenetskaya TA (1998). Regulation of apoptosis by a-subunits of G12 and Gproteins viaapoptosis signal-regulating kinase-1. J Biol Chem 273,27 816-23. Berlot CH and Bourne HR (1992). Identification of effector-activating residues of Gsa. Cell 68,911-22. Berman HM, Bhat TN, Bourne PE etal. (2000). The protein data bank and the challenge of structural genomics. Nature Structural Biol 7, 957-9. Berstein G, Blank JL, Jhon DY, Exton JH, Rhee SG, and Ross EM (1992). Phospholipase C-ß1 is a

GTPase-activating protein for Gq/11, its physiologic regulator. Cell 70, 411-8. Bourne HR (1997). How receptors talk to trimeric G proteins. Curr Opin Cell Biol 9, 134-42. Bourne HR, Sanders DA, and McCormick F (1990). The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348, 125-32. Bourne HR, Sanders DA, and McCormick F (1991). The GTPase superfamily: conserved structure and molecular mechanism. Nature 349, 117-27.

Cai K, Itoh Y, and Khorana HG (2001). Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: use of a photoactivatable reagent. Proc Natl Acad Sci USA 98, 4877-82.

Casey PJ and SeabraMC (1996). Protein prenyltransferases. J Biol Chem 271, 5289-92.

Chen CA and Manning DR (2001). Regulation of G proteins by covalent modification. Oncogene 20, 1643-52.

Chen LT, Gilman AG, and Kozasa T (1999). A candidate target for G protein action in brain. J Biol Chem 274, 26 931-8.

Cismowski MJ, Takesono A, Bernard ML, Duzic E, and Lanier SM (2001). Receptor-independent activators of heterotrimeric G-proteins. Life Sci 68, 2301-8.

Clapham DE and Neer EJ (1997). G protein ßY subunits. Ann Rev Pharmacol Toxicol 37, 167-203.

Collins LR, Minden A, Karin M, and Brown JH (1996). Gai2 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac. J Biol Chem 271, 17 349-53.

Conklin BR and Bourne HR (1993). Structural elements of Ga subunits that interact with GßY, receptors, and effectors. Cell 73, 631-41.

Conklin BR, Farfel Z, Lustig KD, Julius D, and Bourne HR (1993). Substitution of three amino acids switches receptor specificity of Gqa to that of Gia. Nature 363, 274-6.

Conklin BR, Herzmark P, Ishida S etal. (1996). Carboxyl-terminal mutations of Gqa and Gsa that alter the fidelity of receptor activation. Mol Pharmacol 50, 885-90.

Corvol JC, Studler JM, Schonn JS, Girault JA, and Herve D (2001). Gaolf is necessary for coupling D1 and A2a receptors to adenylyl cyclase in the striatum. J Neurochem 76, 1585-8.

DeVriesL, MousliM, Wurmser A, and Farquhar MG (1995). GAIP, a protein that specifically interacts with the trimeric G protein Gai3, is a member of a protein family with a highly conserved core domain. Proc Natl Acad Sci USA 92, 11 916-20.

De Vries L, Zheng B, Fischer T, Elenko E, and Farquhar MG (2000). The regulator of G protein signaling family. Ann Rev Pharmacol Toxicol 40, 235-71.

Dryja TP, Hahn LB, Reboul T, and Arnaud B (1996). Missense mutation in the gene encoding the a subunit of rod transducin in the Nougaret form of congenital stationary night blindness. Nature Genet 13, 358-60.

Duncan JA and Gilman AG (1996). Autoacylation of G protein alpha subunits. J Biol Chem 271, 23 594-600.

EcheverriaV, HinrichsMV, TorrejonM etal. (2000). Mutagenesis in the switch IV of the helical domain of the human Gsa reduces its GDP/GTP exchange rate. J Cell Biochem 76, 368-75.

Exner T, Jensen ON, Mann M, Kleuss C, and Nurnberg B (1999). Posttranslational modification of Gao1 generates Gao3, an abundant G protein in brain. Proc Natl Acad Sci USA 96, 1327-32.

Ford CE, Skiba NP, Bae H etal. (1998). Molecular basis for interactions of G protein ßY subunits with effectors. Science 280, 1271-4.

Fukuhara S, Murga C, Zohar M, Igishi T, and Gutkind JS (1999). A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem 274, 5868-79.

Gasman S, Chasserot-Golaz S, Popoff MR, Aunis D, and Bader MF (1997). Trimeric G proteins control exocytosis in chromaffin cells. Go regulates the peripheral actin network and catecholamine secretion by a mechanism involving the small GTP-binding protein Rho. J Biol Chem 272, 20 564-71.

Ghose S, Porzig H, and Baltensperger K (1999). Induction of erythroid differentiation by altered Ga16 activity as detected by a reporter gene assay in MB-02 cells. J Biol Chem 274, 12 848-54.

Gilbertson TA, Damak S, and Margolskee RF (2000). The molecular s physiology of taste transduction. Curr Opin Neurobiol 10, 519-27.

GilmanAG (1987). Gproteins: transducers of receptor-generated signals. Ann Rev Biochem 56, 615-49.

Grishina G and Berlot CH (2000). A surface-exposed region of Gsa in which substitutions decrease receptor-mediated activation and increase receptor affinity. Mole Pharmacol 57, 1081-92.

Gu C, Ma YC, Benjamin J, Littman D, Chao MV, and Huang XY (2000). Apoptotic signaling through the ß-adrenergic receptor. A new Gs effector pathway. J Biol Chem 275, 20 726-33.

Gudermann T, Schoneberg T, and Schultz G (1997). Functional and structural complexity of signal transduction via G-protein-coupled receptors. Ann Rev Neurosci 20, 399-427.

Guex N and Peitsch MC (1997). SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18, 2714-23.

Hamm HE (1998). The many faces of G protein signaling. J Biol Chem 273, 669-72.

Hamm HE, Deretic D, Arendt A, Hargrave PA, Koenig B, and Hofmann KP (1988). Site of G protein binding to rhodopsin mapped with synthetic peptides from the a subunit. Science 241, 832-5.

Hart MJ, Jiang X, KozasaT etal. (1998). Direct stimulation of the guanine nucleotide exchange activity ofp115 RhoGEF by Ga13. Science 280,2112-4.

Heasley LE, Zamarripa J, Storey B etal. (1996). Discordant signal transduction and growth inhibition of small cell lung carcinomas induced by expression of GTPase-deficient Ga16. J Biol Chem 271, 349-54.

Hendry IA, Kelleher KL, Bartlett SE et al. (2000). Hypertolerance to morphine in Gza -deficient mice. Brain Res 870, 10-19.

Herlitze S, Garcia DE, Mackie K, Hille B, Scheuer T, and Catterall WA (1996). Modulation of Ca2+ channels by G-protein beta gamma subunits. Nature 380, 258-62.

Ho MK and Wong YH (1998). Structure and function of the pertussis-toxin-insensitive Gz protein. Biol Signals and Receptors 7, 80-9.

Ho MK and Wong YH (2000). The amino terminus of Gaz is required for receptor recognition, whereas its a4/ß6 loop is essential for inhibition of adenylyl cyclase. Mol Pharmacol 58, 993-1000.

Ho MK and Wong YH (2001). Gz signaling: emerging divergence from Gi signaling. Oncogene 20, 1615-25.

Ho MK, Yung LY, Chan JS, Chan JH, Wong CS, and Wong YH (2001). Ga14 links a variety of Gi- and Gs-coupled receptors to the stimulation of phospholipase C. Brit J Pharmacol 132, 1431-40.

Hooley R, Yu CY, Symons M, and Barber DL (1996). Ga13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways. J Biol Chem 271, 6152-8.

Hoon MA, Adler E, Lindemeier J, Battey JF, Ryba NJ, and Zuker CS (1999). Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 96, 541-51.

Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, and Shizuya H (2000). Genomic characterization of the human heterotrimeric G protein a, ß, and y subunit genes. DNA Res 7, 111-20.

Igarashi M, Strittmatter SM, Vartanian T, and Fishman MC (1993). Mediation by G proteins of signals that cause collapse of growth cones. Science 259, 77-9.

Iismaa SE, Wu MJ, Nanda N, Church WB, and Graham RM (2000). GTP binding and signaling by Gh/transglutaminase II involves distinct residues in a unique GTP-binding pocket. J Biol Chem 275, 18 259-65.

Ishikawa K, Imai Y, Katsuya T et al. (2000). Human G-protein ß3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure. Am J Hypertension 13, 140-5.

Itoh H and Gilman AG (1991). Expression and analysis of Gsa mutants with decreased ability to activate adenylylcyclase. J Biol Chem 266, 16 226-31.

Itoh Y, Cai K, and Khorana HG (2001). Mapping of contact sites in complex formation between light-activated rhodopsin and transducin by covalent crosslinking: use of a chemically preactivated reagent. Proc Natl Acad Sci USA 98, 4883-7.

Jiang Y, Ma W, Wan Y, Kozasa T, Hattori S, and Huang XY (1998). The G protein Ga12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. Nature 395, 808-13.

Johnson RS, Ohguro H, Palczewski K, Hurley JB, Walsh KA, and Neubert TA (1994). Heterogeneous N-acylation is a tissue-and species-specific posttranslational modification. J Biol Chem 269,21067-71.

Jordan JD, Carey KD, Stork PJ, and Iyengar R (1999). Modulation of rap activity by direct interaction of Gao with Rap1 GTPase-activating protein. J Biol Chem 274, 21 507-10.

Kleuss C, Hescheler J, Ewel C, Rosenthal W, Schultz G, and Wittig B (1991). Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 353, 43-8.

Kostenis E, Degtyarev MY, Conklin BR, and Wess J (1997). The N-terminal extension of Gaq is critical for constraining the selectivity of receptor coupling. J Biol Chem 272, 19 107-10.

Kovoor A, Chen CK, He W, Wensel TG, Simon MI, and Lester HA (2000). Co-expression of Gß5 enhances the function of two Gy subunit-like domain-containing regulators of G protein signaling proteins. J Biol Chem 275, 3397-402.

KozasaT, Jiang X, Hart MJ etal. (1998). p115 RhoGEF, a GTPase activating protein for Ga12 andGa13. Science 280,2109-11.

Lai RK, Perez-Sala D, Canada FJ, and Rando RR (1990). The y subunit of transducin is farnesylated. Proc Natl Acad Sci USA 87, 7673-7.

Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, and Sigler PB (1996). The 2.0Ä crystal structure of a heterotrimeric G protein. Nature 379, 311-9.

Lee CH, Katz A, and Simon MI (1995). Multiple regions of Ga16 contribute to the specificity of activation by the C5a receptor. Mol Pharmacol 47, 218-23.

Lerman BB, Dong B, Stein KM, Markowitz SM, Linden J, and Catanzaro DF (1998). Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunit aj2. J Clini Invest 101, 2862-8.

Lichtarge O, Bourne HR, and Cohen FE (1996). Evolutionarily conserved Gaßy binding surfaces support a model of the G protein-receptor complex. Proc Natl Acad Sci USA 93, 7507-11.

Lin P, Fischer T, Weiss T, and Farquhar MG (2000). Calnuc, an EF-hand Ca(2+). binding protein, specifically interacts with the C-terminal a5-helix of Gai3. Proc Natl Acad Sci USA 97, 674-9.

Lin X, Voyno-Yasenetskaya TA, Hooley R, Lin CY, Orlowski J, and Barber DL (1996). Gai2 differentially regulates Na+-H+ exchanger isoforms. J Biol Chem 271, 22 604-10.

Liu X, Malbon CC, and Wang HY (1998). Identification of amino acid residues of Gsa critical to repression of adipogenesis. J Biol Chem 273, 11 685-94.

Loew A, Ho YK, Blundell T, and Bax B (1998). Phosducin induces a structural change in transducin ßy. Structure 6, 1007-19.

Lopez I, Mak EC, Ding J, Hamm HE, and Lomasney JW (2001). A novel bifunctional phospholipase C that is regulated by Ga12 and stimulates the Ras/mitogen-activated protein kinase pathway. J Biol Chem 276, 2758-65.

Luo Y and Denker BM (1999). Interaction of heterotrimeric G protein Gao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor. J Biol Chem 274, 10 685-8.

LupiR, CordaD, and Di Girolamo M (2000). Endogenous ADP-ribosylation of the G protein ß subunit prevents the inhibition of type 1 adenylyl cyclase. J Biol Chem 275, 9418-24.

Lyons J, Landis CA, Harsh G et al. (1990). Two G protein oncogenes in human endocrine tumors. Science 249, 655-9.

Ma YC, Huang J, Ali S, Lowry W, and Huang XY (2000). Src tyrosine kinase is a novel direct effector of G proteins. Cell 102, 635-46.

Meigs TE, Fields TA, McKee DD, and Casey PJ (2001). Interaction of Ga12 and Ga13 with the cytoplasmic domain of cadherin provides a mechanism for ß-catenin release. Proc Natl Acad Sci USA 98, 519-24.

Meirhaeghe A, Bauters C, Helbecque N et al. (2001). The human G-protein ß3 subunit C825T polymorphism is associated with coronary artery vasoconstriction. Eur Heart J 22, 845-8.

Mody SM, Ho MK, Joshi SA, and Wong YH (2000). Incorporation of Gaz-specific sequence at the carboxyl terminus increases the promiscuity of Gai6 toward Gi-coupled receptors. Mol Pharmacol 57, 13-23.

Moxham CM and Malbon CC (1996). Insulin action impaired by deficiency of the G-protein subunit Gia2. Nature 379, 840-4.

Murtagh JJ Jr, Moss J, and Vaughan M (1994). Alternative splicing of the guanine nucleotide-binding regulatory protein Goa generates four distinct mRNAs. Nucleic Acids Res 22, 842-9.

Nakamura F, Ogata K, Shiozaki K et al. (1991). Identification of two novel GTP-binding protein a-subunits that lack apparent ADP-ribosylation sites for pertussis toxin. J Biol Chem 266, 12 676-81.

Nakamura K, Nukada T, Haga T, and Sugiyama H (1994). G protein-mediated inhibition of phos-phoinositide metabolism evoked by metabotropic glutamate receptors in frog oocytes. J Physiol 474,35-41.

Nakaoka H, Perez DM, BaekKJ etal. (1994). Gh a GTP-binding protein with transglutaminase activity and receptor signaling function. Science 264, 1593-6.

Neer EJ, Schmidt CJ, Nambudripad R, and Smith TF (1994). The ancient regulatory-protein family of WD-repeat proteins. Nature 371, 297-300.

Offermanns S (2001). In vivo functions of heterotrimeric G-proteins: studies in Ga-deficient mice. Oncogene 20, 1635-42.

Offermanns S and Simon MI (1995). Ga15 and Ga16 couple a wide variety of receptors to phospholipase C. J Biol Chem 270, 15 175-80.

Osawa S, Dhanasekaran N, Woon CW, and Johnson GL (1990). Gai-Gas chimeras define the function of a chain domains in control of G protein activation and ßy subunit complex interactions. Cell 63, 697-706.

Osawa S and Johnson GL (1991). A dominant negative Gas mutant is rescued by secondary mutation of the a chain amino terminus. J Biol Chem 266, 4673-6.

Palczewski K, Kumasaka T, Hori T etal. (2000). Crystal structure of rhodopsin: A G protein-coupled receptor. Science 289, 739-45.

Peifer M and Polakis P (2000). Wnt signaling in oncogenesis and embryogenesis—a look outside the nucleus. Science 287, 1606-9.

Philips MR, Staud R, Pillinger M et al. (1995). Activation-dependent carboxyl methylation of neutrophil G-protein y subunit. Proc Natl Acad Sci USA 92, 2283-7.

Popova JS, Johnson GL, and Rasenick MM (1994). Chimeric Gas/Gaj2 proteins define domains on Gas that interact with tubulin for ß-adrenergic activation of adenylyl cyclase. J Biol Chem 269, 21 748-54.

Prasad MV, Dermott JM, Heasley LE, Johnson GL, and Dhanasekaran N (1995). Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of Ga12 and Ga13. J Biol Chem 270, 18 655-9.

Rahmatullah M and Robishaw JD (1994). Direct interaction of the a and y subunits of the G proteins. Purification and analysis by limited proteolysis. JBiol Chem 269, 3574-80.

Ram PT, Horvath CM, and Iyengar R (2000). Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Gao protein. Science 287, 142-4.

Ronnett GV and Snyder SH (1992). Molecular messengers of olfaction. Trends in Neurosci 15, 508-13.

Rudolph U, Finegold MJ, Rich SS etal. (1995). Gj2a protein deficiency: a model of inflammatory bowel disease. J Clin Immunol 15, 101-5.

Rymer DL and Good TA (2001). The role of G protein activation in the toxicity of amyloidogenic Aß-(1-40), Aß-(25-35), and bovine calcitonin. J Biol Chem 276, 2523-30.

Siffert W (2000). G protein ß3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy. Nephrology, Dialysis, Transplantation 15, 1298-306.

Siffert W, Rosskopf D, Siffert G etal. (1998). Association of a human G-protein ß3 subunit variant with hypertension. Nature Genetics 18, 45-8.

Simon MI, Strathmann MP, and Gautam N (1991). Diversity of G proteins in signal transduction. Science 252, 802-8.

SimondsWF and Zhang JH (2000). New dimensions in G protein signalling: Gß5 and the RGS proteins. Pharmaceutica Acta Helvetiae 74, 333-6.

Smine A, Xu X, Nishiyama K et al. (1998). Regulation of brain G-protein Go by Alzheimer's disease gene presenilin-1. J Biol Chem 273, 16 281-8.

Sondek J and Siderovski DP (2001). Gy-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding. Biochem Pharmacol 61, 1329-37.

Sowell MO, Ye C, Ricupero DA etal. (1997). Targeted inactivation of ai2 or ai3 disrupts activation of the cardiac muscarinic K+ channel, IK+ Ach, in intact cells. Proc Natl Acad Sci USA 94, 7921-6.

Sprang SR (1997). G proteins, effectors and GAPs: structure and mechanism. Curr Opin Struct Biol 7, 849-56.

Stanners J, Kabouridis PS, McGuire KL, and Tsoukas CD (1995). Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling. J Biol Chem 270, 30 635-42.

Strittmatter SM, Valenzuela D, Sudo Y, Linder ME, and Fishman MC (1991). An intracellular guanine nucleotide release protein for Go. GAP-43 stimulates isolated a subunits by a novel mechanism. J Biol Chem 266, 22 465-71.

Tanaka M, Treloar H, Kalb RG, Greer CA, and Strittmatter SM (1999). Go protein-dependent survival of primary accessory olfactory neurons. Proc Natl Acad Sci USA 96, 14106-11.

Taussig R, Tang WJ, and Gilman AG (1994). Expression and purification of recombinant adenylyl cyclases in Sf9 cells. Meth Enzymol 238, 95-108.

Tolkacheva T, Feuer B, Lorenzi MV, Saez R, and Chan AM (1997). Cooperative transformation of NIH3T3 cells by Ga12 and Rac1. Oncogene 15, 727-35.

Ueda H, Yamauchi J, Itoh H etal. (1999). Phosphorylation of F-actin-associating G protein y12 subunit enhances fibroblast motility. J Biol Chem 274, 12 124-8.

Virchow S, Ansorge N, Rosskopf D, Rubben H, and Siffert W (1999). The G protein ß3 subunit splice variant Gß3-s causes enhanced chemotaxis of human neutrophils in response to interleukin-8. Naunyn Schmiedebergs Archives in Pharmacol 360, 27-32.

Wall MA, Coleman DE, Lee E etal. (1995). The structure ofthe G protein heterotrimer Gia1ß1y2. Cell 83, 1047-58.

Wang HY and Malbon CC (1996). The G sa/Gia2 axis controls adipogenesis independently of adenylylcyclase. Inter J Obes Relat Metab Disord 20, S26-31.

Wang HY and Malbon CC (1999). Gsa repression of adipogenesis via Syk. J Biol Chem 274, 32159-66.

Wang N, Yan K, and Rasenick MM (1990). Tubulin binds specifically to the signal-transducing proteins, Gsa and Gia1. J Biol Chem 265, 1239-42.

Wang Q, Mullah BK, and Robishaw JD (1999). Ribozyme approach identifies a functional association between the G protein ß1y7 subunits in the ß-adrenergic receptor signaling pathway. J Biol Chem 274, 17365-71.

Wedegaertner PB and Bourne HR (1994). Activation and depalmitoylation of Gsa. Cell 77, 1063-70.

Wedegaretner PB, Wison PT, and Bourne HR (1995). Lipid modifications oftrimeric G proteins. J Biol Chem 270, 503-6.

Weinstein LS and Yu S (1999). The Role of Genomic imprinting of Ga in the pathogenesis of Albright hereditary osteodystrophy Trends Endocrinol Metab 10, 81-5.

Williamson EA, Johnson SJ, Foster S, Kendall-Taylor P, and Harris PE (1995). G protein gene mutations in patients with multiple endocrinopathies. J Clin Endocrinol Metab 80, 1702-5.

Wong GT, Gannon KS, and Margolskee RF (1996). Transduction of bitter and sweet taste by gustducin. Nature 381, 796-800.

Wong YH, Conklin BR, and Bourne HR (1992). Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science 255, 339-42.

Yan K, Kalyanaraman V, and Gautam N (1996). Differential ability to form the G protein ßY complex among members ofthe ß and y subunit families. J Biol Chem 271, 7141-6.

Yan W, Sunavala G, Rosenzweig S, Dasso M, Brand JG, and Spielman AI (2001). Bitter taste transduced by PLC-ß2-dependent rise in IP3 and a-gustducin-dependent fall in cyclic nucleotides. American J Physiol Cellular Physiol 280, C742-51.

Yang J, Wu J, Kowalska MA et al. (2000). Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci USA 97, 9984-9.

Zhou J, Stanners J, Kabouridis P, Han H, and Tsoukas CD (1998). Inhibition of TCR/CD3-mediated signaling by a mutant of the hematopoietically expressed G16 GTP-binding protein. Eur J Immunol 28, 1645-55.

0 0

Post a comment