a2C-adrenoceptors appear to be involved in the startle reflex and isolation induced aggression, since knockout of a2c-adrenoceptors in mice results in an enhanced startle response and shortened attack latency, whereas overexpression of this receptor produced the opposite effect on both parameters (Sallinen etal. 1998). Behavioural despair in the forced swimming test was enhanced or inhibited by a2c-adrenoceptor overexpression or knockout, respectively (Sallinen etal. 1999).
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