Dopamine D1 receptors are widely distributed within the brain, with high densities found in the striatum, nucleus accumbens, olfactory tubercle, and frontal cortex (Tiberi et al. 1991). Overall, in the central nervous system (CNS) the D1 (and D2) receptors show the highest densities when compared to the other dopamine receptor subtypes.
The D5 receptor mRNA is most abundant in hippocampus, hypothalamus, and midbrain (Tiberi etal. 1991; Sunahara etal. 1991;Laurier etal. 1994), with lower levels detected in the striatum but at ~1/10 the abundance of the D1 receptor mRNA.
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