Exogenous and endogenous cannabinoids reduce hypoxic neuronal damage in cell culture and are neuroprotective in animal models of global and focal ischemia. These effects appear to be mediated via CB1 receptors and an induction of CB1 protein has been reported in an experimental stroke model (Jin et al. 2000). There is a major loss of cannabinoid receptor binding in post mortem brains from Huntington's patients. In particular, there is drop out of binding in the substantia nigra (Glass et al. 1993) and globus pallidus (Richfield and Herkenham 1994).
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