Cns

Figure 7.2 Expression of integrins and immune molecules in the active MS lesion. Integrins are expressed and regulated on endothelial, neural and infiltrating mononuclear cells in MS. Together with other immunomodulating molecules present on the surface of these cells, they contribute to the development and maintenance of the inflammatory process. cICAM-1 and cVCAM-1, circulating integrin ligands, are elevated in remitting-relapsing MS and correlate with disease activity on cranial MRI. Only the expression patterns described in MS lesions are listed. Data from EAE, although they may apply to MS, are not included. B7, B-cell activation antigen B7; CD40L (CD154), ligand of CD40; CXR, chemokine receptors; ICAM-3 (CD50), intercellular cell adhesion molecule-3; LFA-3 (CD58), lymphocyte function-associated molecule-3; VCAM-1 (CD106), vascular cell adhesion molecule-1.

Figure 7.2 Expression of integrins and immune molecules in the active MS lesion. Integrins are expressed and regulated on endothelial, neural and infiltrating mononuclear cells in MS. Together with other immunomodulating molecules present on the surface of these cells, they contribute to the development and maintenance of the inflammatory process. cICAM-1 and cVCAM-1, circulating integrin ligands, are elevated in remitting-relapsing MS and correlate with disease activity on cranial MRI. Only the expression patterns described in MS lesions are listed. Data from EAE, although they may apply to MS, are not included. B7, B-cell activation antigen B7; CD40L (CD154), ligand of CD40; CXR, chemokine receptors; ICAM-3 (CD50), intercellular cell adhesion molecule-3; LFA-3 (CD58), lymphocyte function-associated molecule-3; VCAM-1 (CD106), vascular cell adhesion molecule-1.

I I ec\

(b)

( II EC I

• • • • ••

Was this article helpful?

0 0
Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment