"1 I I I I I I 1 2 3 4 5 6 7

Blocks of trials (8/block)

Figure 21.2 T-maze performance by control BALB/c mice (■), BALB/c immunized with 02-GPI (▲) a BALB/c mice treated with a-ICAM monoclonal antibody (♦). The mean of correct choices displayed by the mice is depicted. Mice immunized with 02-GPI demonstrated a significant deficit choosing the correct arm on the choice trials, compared to the controls, which were immunized with BSA. A trend for improvement in performance of the task was achieved in the anti-ICAM-treated mice.

high-dose intravenous immunoglobulins. IVIg was successful in in vitro inhibition of anti-cardiolipin antibodies and lupus anticoagulant55 and in the amelioration of experimental APS.56 The most recent research supports the future inhibition of expression of adhesion molecules.

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