Accelerated Muscular Development Programs

Isometrics Mass Exercises

Isometric Mass is the most revolutionary fitness program in the market right now. It is the great way of training to build muscle in short time and increase the testosterone in the blood, a way that proved to help even 40th and 50th men to overcome their age boundaries and build beautiful muscle and improve their health with less than 30 min training every day. Isometric mass program helped me build muscle with less effort in less time and saved me time and money because the isometric system doesn't need fancy equipment and count only on body weight. The program is divided into basic set of DVDs and bonus set. The basic set cover everything from quick start guide, instructional video library for the isometric techniques, isometric mass workout guide which will save you all your costs you used to pay for trainers and gym. The last basic product is an isometric printable logs to help you keep track of your workout and progress. The bonus part of the isometric mass is very cool because it contain the body weight edition of the isometric system, a great done-for-you meal plan that fits greatly into the isometric system and the last bonus product is a great guide for using supplements which could make you finally understand the art and science of taking supplements. Isometric mass is a great program every muscle builder should have. Continue reading...

Isometrics Mass Summary

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Contents: Ebooks, Videos, Meal Plan
Author: Alby Gonzalez
Official Website: isometricsmass.com
Price: $9.00

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The writer has done a thorough research even about the obscure and minor details related to the subject area. And also facts weren’t just dumped, but presented in an interesting manner.

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Physique Zero

The name of the author is Alain Gonzalez who is a fitness coach and a long time author. This guy wants to help millions of people all over the world especially those that don't have enough time to train at the GYM. On his prior work, this man wanted to help skinny guys but later noticed that people of all ages, and body sizes needed help to build muscles too. With a busy family life, he believes that you can as well use the little time you have to build muscles and at the same time become fit. With this program, you will eliminate some of the things that you thought mattered the most to build muscles. As a matter of fact, the author dedicated some time to conduct research and later develop a powerful system that is easy to follow and that will help you build muscles without 'GYMing''. Upon purchasing, you will get the main product in form of a downloadable PDF formats. The author has also included some videos to show you exactly what you are supposed to do. This program is for anyone that wants to get leaner, stronger and get more energy with ease regardless of their social status, age and race. Continue reading...

Physique Zero Summary

Contents: Ebooks
Author: Alain Gonzalez
Official Website: projecthypertrophy.com
Price: $15.00

The Muscle Maximizer

The first truly custom, interactive, professional nutrition system proven to explode lean muscle growth without any fat. The systems 4 patented formulas are the true keys to unlocking more muscle growth than you thought possible. Formula 1 is the Sometabolic Customizer You will discover your exact calorie and macronutrient needs to build pure lean muscle using the systems advanced somatotyping techniques. You will also find out exactly what and when to eat based around your weight training regimen to catapult your body into a 24/7 muscle building state. Formula 2 is the Somanabolic Rebuilder This is for your off days. Your recovery nutrition is custom structured to repair and rebuild your broken down muscle tissue quickly. Using unique calorie and macronutrient shifting techniques your muscle recovery is extremely rapid and muscle soreness is often 100 % eliminated. Formula 3 is the ever so important Systematic Nutrabolism This is the key for up to 84% of all your lean muscle growth. Continue reading...

The Muscle Maximizer Summary

Official Website: www.themusclemaximizer.com
Price: $47.00

RDS Physique Building Program

Dean RSD is the founder and creator of the ebook of your dreams, after years of failure in the fitness industry using the same ways that get you to the average physique, he has been able to step into his best body and one of the most impressive builds ever seen using the latest scientific research. He put on all of this information in an ebook that contains all the information you need in order to get big bulging lean muscles that will leave everyone in awe. You will get access to the best information out there in the diet and training that many people have already benefited from. With no cardio, smart nutrition and training techniques, you are a few seconds away from the reveal of the secrets of the bodybuilders. You will achieve a great body naturally with no need for steroids and you will no longer need any advice from anyone. With this easy reader-friendly ebook, you will shock everyone, boost your confidence, get stronger, leaner and more muscular. Dean will share this information in his ebook that is easy to attain. You can read this on your way to the gym, on your way to work and in your free to benefit from all the information and make use of it. Continue reading...

RDS Physique Building Program Summary

Contents: Ebook
Author: Dean
Official Website: www.rdsphase2.com
Price: $27.00

Rac Gene In Development

In Drosophila melanogaster, the homologs of Racl, Rac2, and Cdc42 have been named Dracl, Drac2, and DCdc42, respectively (Van Aelst and D'Souza-Schorey, 1997). These genes are highly expressed in the nervous system and in the mesoderm during neuronal and muscle development (Luo et al., 1996). In developing neurons, studies have shown that the expression of constitutively activated or dominant-negative mutants of DRacl perturbed the initiation and elongation of axonal outgrowth. These perturbations appear to result from defects in the actin cytoskeleton and that the oscillation of DRacl between its GTP and GDP states is critical for the developing axon (Luo et al., 1996). In the presence of active DRacl, the accumulation of F-actin in the dorsal neuronal clusters persisted through later stages of development, whereas no F-actin accumulation was observed in the presence of a dominant-negative Dracl. Furthermore, DRacl and DCdc42 regulate muscle development most likely by their effects...

Muscle Damage and ROS

5.6 Isometric Exercise and Oxidative Stress According to the exercise continuum, skeletal muscle contractions fall along a range with isometric at one end and isotonic at the other. In reality, most muscle contractions are somewhere in between the two extremes. Generation of force depends on proper alignment or overlap of actin and myosin filaments. In isometric contractions, no sliding movement occurs between actin and myosin, nevertheless, an active tension exists between the two myofilaments that allows for cross bridges to form and for tension to develop. Despite little to no muscle movement, evidence of oxidative stress has been observed during isometric exercise (Alessio et al., 2000). Causes of oxidative stress during isometric exercise include elevated intracellular calcium that gets trapped inside the sarcomere during an isometric contraction, autooxidation of catecholamines released during intensive isometric contractions, rapid depletion of ATP stores, lactic acid...

Exercise Hypoxia and Oxidative Stress

Participated in six months of resistance training and compared biomarkers of oxidative stress following acute aerobic exercise. They reported that resistance training reduced serum lipox following aerobic exercise and provided protection against oxidizing agents in vitro. They concluded that resistance training provided a cross-protection against aerobic-exercise induced oxidative stress and they attributed this protection to increased GSH levels.

Perturbing the System Effects of Cytokines

Exercise is among the most effective interventions for loss of function in aging muscle. Although the conditioning process is prolonged in aged-muscle, a well-designed strength-training program can safely increase muscle mass, strength and function (Roth et al., 2000 Hebuterne et al, 2001). By definition, the exercise bouts that are used for training will transiently elevate tissue ROS and NO levels. In young adults, such training evokes adaptive responses in skeletal muscle fibers. These include an increase in antioxidant enzyme activity that renders the muscle more resistant to oxidative stress (Powers et al., 1999). HSP levels are also up-regulated in trained muscle (McArdle and Jackson, 2000 Naito et al., 2001), which further contributes to cytoprotection. Concerns have been raised that aging may limit the capacity of muscle to adapt in this manner (Spiers et al., 2000). Although HSP expression appears to be blunted with age, the increases in antioxidant enzyme activities that...

HDACs and Differentiation

The myocyte enhancer factor 2 (MEF2) was originally identified as a muscle differentiation related-transcription factor involved in the regulation of skeletal muscle development and the stress-response of cardiomyocytes (Lilly et al. 1994 Zhang et al. 2002). Interestingly, MEF2-dependent myogenesis may be simultaneously controlled by three HDACs HDAC3, HDAC4, and SIRT1 (Zhao et al. 2005 Gregoire et al. 2007). SIRT1 and HDAC3, but not HDAC4, are capable of

HDACs in Skeletal Muscle Regeneration

A few studies have suggested that HDACs may play a role in muscle regeneration and satellite cell activation. TIS7 is a transcriptional corepressor important to muscle cell regeneration. TIS7-null mice display a delay in injury-induced muscle regeneration and reduced expression of MRFs, MyoD and myogenin, despite normal muscle development (Vadivelu et al. 2004). Apparently, the satellite cells of TIS7-null mice have a decreased capacity for differentiation. TIS7 transcriptional repression is HDAC-dependent, requiring HDAC1 and possibly HDAC4 as well (Vietor et al. 2005). Conversely, HDAC inhibitors (HDACIs) have proven therapeutically useful in treating mouse models of muscular dystrophies by enhancing muscle regeneration (Colussi et al. 2008 Minetti et al. 2006). The beneficial effects of HDACIs in the treatment of muscular dystrophy are derived from their influence upon the follistatin-myostatin pathway (Iezzi et al. 2004). Myostatin belongs to the TGF-p family and negatively...

Cross Training Sports and Oxidative Stress

Table 5.1 includes a list and brief description of research studies that have investigated oxidative stress in specific sports. Most sports include muscle movements that cover the majority muscle actions of the exercise continuum. Some, like weight lifting and resistance training lean more toward the isometric end of the continuum, while others such as running and soccer lean more towards the rhythmic or isotonic end of the continuum. In general, most studies of different sports agree that trained athletes have superior antioxidant defense systems in place that can prevent the accumulation of oxidative stress biomarkers during submaximal exercise. However, during and following maximal exercise efforts, even the most trained athletes experience signs and symptoms of metabolic and mechanical stress in the form of oxidative stress byproduct accumulation (e.g. increased MDA, LH, 8-OH-dG, CD, TBARS, PC) or muscle damage (e.g. CK, 3-methyl histidine, muscle soreness). Biomarkers of...

HDACs in Fiber Type Specification

Inactivation of HDAC genes in mouse models have been performed for all class I and class IIa HDACs. HDAC4-null mice die shortly after birth with labored breathing due to abnormal ossification of the rib cage (Vega et al. 2004), whereas HDAC5- and HDAC9-null mice are viable, but develop cardiac hypertrophy due to increased responsiveness to calcineurin-mediated MEF2 transcriptional activation (Zhang et al. 2002b Chang et al. 2004). In HDAC4, HDAC5, and HDAC9-null mouse models, there was no report of any grossly abnormal skeletal muscle phenotype (Potthoff et al. 2007a). However, analysis of class IIa HDAC mutant mice revealed that a combined inactivation of any two class IIa HDACs (HDAC4, -5, or -9) lead to an increase in type I slow-oxidative muscle fiber composition while skeletal muscle development proceeds normally (Potthoff et al. 2007a). These findings reveal that class IIa HDACs play an instructive but redundant role in muscle fiber type specification. The aberrant induction of...

Specification of Myofibers

Importantly, the adult myofiber phenotype is not permanent. The size, contractility, and metabolic properties of myofibers can all undergo changes or remodeling reviewed in Bassel-Duby and Olson (2006) . For example, reduced neuromuscular activity caused by inactivity, aging or neuromuscular disease can lead to reduction in muscle size, termed atrophy. Inactivity also causes an increase in fast-glycolytic fibers. Conversely, repetitive use such as aerobic exercise induces muscle hypertrophy and a concomitant increase in slow-oxidative fibers. This plasticity, which is central to the physiological adaptation, is necessary for skeletal muscle to meet changing functional demands and perform different tasks. On the other hand, the pathological remodeling of skeletal muscle could lead to serious health problems, such as a loss of muscle mass, termed muscle atrophy (Fig. 1).

Other Signaling Pathways in Skeletal Muscle Remodeling

The final kinase pathway that deserves mention in muscle remodeling involves protein kinase B (PKB) Akt and mammalian target of rapamycin (mTOR). Upon loss of neural input, the activity of Akt is greatly diminished (Pallafacchina et al. 2002). As opposed to the Ras-MAPK pathway, activation of Akt increases myofiber size without affecting fiber type. Akt signaling proceeds through mTOR, as rapamycin is able to ablate the effects of activated Akt on muscle fiber size. Interestingly, this pathway is responsible for muscle hypertrophy occurring in response to muscle overload, such as weightlifting. mTOR phosphorylates its targets, p70S6K and PHS-1 4E-BP1, in order to increase protein synthesis and myofiber size. A number of different stimuli can activate this pathway, including growth factors such as insulin-like growth factor-I (IGF-1). Thus, it seems kinase signaling, especially the Ras-MAPK and Akt-mTOR pathways, provide additional mechanisms to fine-tune myofiber size and type....

Sprint Exercise and Oxidative Stress

Sprinting is an example of a predominantly anaerobic exercise where the majority of energy transfer is derived from the phosphagen system with little dependence on oxygen flux. Sprinting shares some characteristics of isometric exercise although there is clearly muscle movement involved in sprinting. Some characteristics shared by both isometric and sprinting exercises include high power output and generation of force, low dependence on oxygen for ATP, persistent action potential across the sarcolemma, rapid degradation of ATP that may continue along the xanthine oxidase pathway, increased heat production, increased intracellular calcium levels, and increased acid levels. Sprinting exercise has been associated with enhanced levels of lipox and other byproducts of ROS (Alessio et al., 1988 Atalay et al., 1996). Atalay et al. (1996) also reported that 6 weeks of sprint training resulted in increased muscle GSH, glutathione S-transferase, and glutathione reductase in Type II muscle...

Ephedra Ma Huang And Related Drugs

Ma huang (ephedra) is commonly found in herbal weight loss products that are often referred to herbal fen-phen. Some weight loss clinics and herbal outlets promote 'Herbal fen-phen' as an alternative to fenfluramine, the prescription drug that has been withdrawn from the market due to toxicity. Herbal fen-phen products sometimes contain St John's wort and are sold as 'herbal prozac'. Ephedra-containing products are also marketed as decongestants, bronchodilators and stimulants. Other promoted uses include bodybuilding and enhancement

Testosterone Testosterone

The steroid testosterone is the principal male sex hormone. The main approved therapeutic use of testosterone is the treatment of testosterone deficiency (hypogonadism). Although testosterone and other anabolic hormones enhance muscle development and improve athletic performance, risks are involved with their use.

Distribution And Pharmacokinetics Of Ghb Gbl And 14bd

As discussed previously, the absorption of GBL has been documented to occur faster than GHB. It has also been proposed that in addition to the better absorption of GBL, it may also distribute differently than GHB. An early study comparing the distribution of equimolar doses of GHB and GBL in rats found that although peak plasma concentrations were higher with GHB they remained elevated longer with GBL. In addition, concentrations of GBL in the lean muscle mass of the rat were always elevated compared with concentrations of GHB (Roth and Giarman, 1966). This suggests sequestration of GBL into lean muscle prior to its conversion to GHB. Since lean muscle does not contain the lactonase enzyme, it is conceivable that this could occur. The GBL could then redistribute into the blood to be

Class IIa Histone Deacetylases Are Potent Regulators of MEF2

Members of the histone deacetylase (HDAC) family have emerged as critical downstream targets of CaMKII in response to neural activity. Specifically, the class IIa HDAC subfamily, which includes HDAC4, HDAC5, HDAC7 and HDAC9, has been intimately linked to MEF2 activity. All class IIa HDACs bind and inhibit MEF2 transcriptional activity (Sparrow et al. 1999 Lu et al. 2000a, b Miska et al. 1999 Wang et al. 1999 Lemercier et al. 2000). They share a common domain structure an N-terminus coiled-coil domain and a C-terminus deacetylase domain (Fig. 2). The N-terminus binds MEF2, transcriptional corepressors, and SUMO-conjugating enzyme Ubc9 (Verdin et al. 2003 Zhang et al. 2002a). Most studies regarding class IIa HDACs in skeletal muscle development has revolved around HDAC4 and HDAC5. HDAC4 and HDAC5 are highly homologous, sharing 51 identity and 63 similarity in their amino acid sequence (Grozinger et al. 1999). Both are potent inhibitors of MEF2-dependent transcription. Indeed,...

Exercise

The literature on exercise is extensive over 20 studies since the 1990 ACR criteria, but the majority of these are of relatively poor quality as they are often open studies, although a limited number are investigator blinded. These studies reported mixed results.65'66'67 However, most experts concurred that aerobic exercise and strength training are beneficial for some FMS patients and this is supported by systematic reviews.68,69,70, 71 iii It should be noted that exercise rarely improves pain, and this symptom can in fact be worsened at first.72 Other factors including function, tender point count, aerobic performance, and global well-being have all been reported to improve. FMS patients are equally able to carry out exercise as healthy people, at levels tailored to each individual. When performing strength training they can experience the same strength gains,73 which may in turn lead to functional improvements and or quality of life. Adherence to a program may be a limiting factor,...

Synthetic steroids

Steroids that aid in muscle development are called anabolic steroids. They are synthetic derivatives of testosterone, thus have the same muscle-building effect as testosterone. There are more than 100 different anabolic steroids which, vary in structure, duration of action, relative effects and toxicities. Androstenedione, stanozolol and dianabol are anabolic steroids. They are used to treat people suffering from traumas accompanied by muscle deterioration. The use of anabolic steroid can lead to a number of dangerous side-effects, including lowered levels of high density lipoprotein cholesterol, which benefits the heart, and elevated levels of harmful low density lipopro-tein, stimulation of prostate tumours, clotting disorders and liver problems.

O Sex Hormones

Testosterone has two primary kinds of activities androgenic (promoting male physical characteristics) and anabolic (muscle building). Many synthetic and semisynthetic androgenic and anabolic steroids have been prepared. Despite efforts to prepare selective anabolic agents (e.g., for use in aiding recovery from debilitating illness or surgery), all anabolic steroids have androgenic effects. The androgenic

Resistive Dynamic

Isometric exercise does not rely on elevated oxygen uptake for energy transfer. Instead the force generated via isometric exercise uses short term energy from the phosphagen system adenosine triphosphate (ATP) diphosphate and creatine phosphate (CP). ATP stores will break down to adenosine (ADP) and supply energy for only 1 to 2 seconds. CP stores will replenish ATP by donating its phosphate (P) to ADP to form ATP in the presence of an enzyme creatine phosphokinase. This process will continue for approximately 8 to 10 seconds. This 10 second exercise duration usually includes high intensity work that results in high ADP and energy transfer. The high ADP levels can act as substrate for ROS just as high oxygen uptake levels do in isotonic exercise, via hypoxanthine (HX) and xanthine (X) that are produced from ADP. One can understand the concept of the exercise continuum, by first asking the question what are the extremes For isometric exercise, it's rather easy to provide examples...

Body Composition

Body composition changes quite significantly with aging. There is an overall reduction in lean muscle mass with an incremental increase in total body fat. These changes cause a corresponding reduction in total body water. It has been estimated that body fat increases by approximately 20-40 and body water decreases by 10-15 in old age (McLean and

Body Building Secrets Revealed

Body Building Secrets Revealed

Ever since the fitness craze in the 1980’s, we have become a nation increasingly aware of our health and physique. Millions of dollars are spent every year in the quest for a perfect body. Gyms are big business, personal trainers are making a tidy living helping people stay fit, and body building supplements are at an all-time level of performance.

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