The topical application of GTN represents a simple, low-risk option for the treatment of localized pain. If this localized pain is associated with localized tenderness the chances of pain relief are increased. The risk of headache, the most common adverse effect associated with GTN use, can be minimized by using as small a dose of GTN as is possible. Because of the lack of effect of GTN on the renal, gastrointestinal and hematological systems, it can be used in place of NSAIDs when disorders of these systems exist when an NSAID may be contraindicated. Topical GTN can be used as a sole analgesic or in combination with other simple analgesics or NSAIDs.

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