It has earlier been described how 5HT3 antagonists can be used to treat fibromyalgia, irritable bowel syndrome, and neuropathic pain. It is now known that they can also be used by the intra-articular route and that the pain relief that is produced is at par with that produced by corticosteroid injection. When given into a joint, there is a clinical impression that they cause a flare of pain that can last for several days, before pain relief is produced. The benefit of use of this class of medication is that it is devoid of the risks associated with repeated corticosteroid injection.
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