Human experimental pain

A small number of studies have examined the effect of IV lidocaine on human experimental pain. Two such experimental paradigms are the subcutaneous injection of capsaicin which causes an acute sensitization of the skin and the application of a heat stimulus. When these stimuli are applied and IV lidocaine administered, the area of secondary hyper-algesia as detected by brush strokes (but not that detected by filament application) is reduced. In an attempt to define whether the effect of the lidocaine is primarily peripheral or central, the effect of systemic IV and regional IV (by isolating the reference limb with a cuff) have been examined. After capsaicin application, both systemic and regional lidocaine slightly reduce capsaicin-related pain. The area of pin-prick hyperalge-sia is significantly reduced after systemic but not after regional lidocaine treatment, suggesting that the effect of IV lidocaine is mediated centrally and not peripherally.

One other experimental model that has been utilized has been that of experimental skin burn in healthy volunteers. When such an injury is inflicted and lidocaine administered, by 12 h after infliction of the burn those treated with lidocaine had a significantly faster resolution of residual erythema compared to controls suggesting that it may have an effect on the long-term inflammation-induced tissues responses to thermal trauma.

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How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

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