Conclusion

Postmortem brain studies, cellular and animal studies, and pharmacological studies suggest the involvement of RNA editing of HTR2C in major mental disorders. However, reported results were tended to be discordant, and observed differences

Table 8.3 Effect of drags on RNA editing of brains of control animals

Drug

Animal

Dose and duration

Findings

Isoform pattern

Reference

Haloperidol

Rat (SD)

1 mg/kg, 14 days

Decrease of D

Increase of VNI. decrease of VNV

Sodhi et al. (2005)

Risperidone

Rat (SD)

0.5 mg/kg. 14 days

Increase of B. decrease of C and D

Increase of VNV

Sodhi et al. (2005)

Clozapine

Rat (SD)

25 mg/kg. 14 days

Not altered

Not altered

Sodhi et al. (2005)

Chlorpromazine

Rat (SD)

15 mg/kg. 14 days

Not altered

Not altered

Sodhi et al. (2005)

Cocaine

Rat (SD)

15 mg/kg. 7 days

Not altered

nd

Iwamoto and Kato (2002)

Reserpine

Rat (SD)

1 mg/kg. 2 days

Not altered

nd

Iwamoto and Kato (2002)

Fluoxetine

Mice (129Sv)

5 mg/kg. 3 days

Decrease of E

Not altered

Gurevich et al. (2002)

Fluoxetine

Mice (129Sv)

5-10 mg/kg. 28 days

Increase of D. decrease of C and E

Increase of VNV

Gurevich et al. (2002)

Fluoxetine

Mice (C57B1/6)

18 mg/kg. 24 days

Not altered

Not altered

Englander et al. (2005)

Fluoxetine

Mice (Balb/c)

18 mg/kg. 24 days

Increase of A. B. C and D

Various changes such

Englander et al. (2005)

as decrease of INI

nd not determined.

as decrease of INI

nd not determined.

were very subtle. Further studies using larger and independent samples are needed.

Acknowledgments This study was supported by Grant-in-Aid from the Japanese Ministry of Health, Welfare, and Labor. We thank Junko Ueda for help in preparation of the manuscript.

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