Together, the data indicate that the snoRNA HBII-52 contributes to alternative splicing regulation of the 5-HT2C receptor. The exact molecular mechanism of the regulation is currently unveiled. The HBII-52 snoRNA is processed into smaller snoRNA fragments (Kishore et al. 2010) that most likely directly influence the 5-HT2C receptor pre-mRNA. Finally, it is likely HBII-52 controls other pre-mRNAs, and it is therefore expected that the 5-HT2C receptor mRNA is not the only deregulated RNA in PWS. However, since mouse models of the 5-HT2C receptor mutants recapitulate some aspects of PWS, we expect that the dysregulation of the receptor plays a decisive role in this disease.

Acknowledgments The laboratory is supported by the Deutsche Forschungsgemeinschaft (DFG), the European Union (EURASNET), and the NIH.

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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