Conclusions

Summarizing studies of 5-HT2C receptor expression and variations in suicide matters, the most complex alterations in 5-HT2C receptor were in the pre-mRNA editing found in brains of depressed suicide victims. In these brains, 5-HT2C receptor isoforms with reduced function are expressed at significantly increased levels, suggesting that the regulation of editing by synaptic 5-HT is defective. Moreover, postmortem studies on brain tissues of patients with schizophrenia and major depression found distinct site-specific alterations of this editing in the PFC, a brain region expressing a large number of differently edited 5-HT2C receptor mRNA isoforms.

Acknowledgments Dr. De Luca has been supported by a NARSAD Young Investigator Award and an American Foundation for Suicide Prevention Pilot Grant.

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