The studies reviewed here show that 5-HT2C receptors are extensive but distributed heterogeneously in the mammalian brain. Although this distribution shows a remarkable similarity among the species, there are nevertheless significant differences that have been identified. Many different neuronal populations including neuropeptidergic, cholinergic, serotonergic and GABAergic as well as the cannabi-noid and dopaminergic systems have been shown to express 5-HT2C receptor mRNA and/or protein. In addition, the distribution suggests the involvement of other transmitter systems such as the glutamatergic and dopaminergic, although colocalization data are still missing. All these chemical neuroanatomical studies clearly point to the role of these receptors in the functions of many brain pathways. The modulation through selective agonists or antagonists of 5-HT2C receptors, an area of intensive research, will reveal the importance of these receptors as therapeutic tools.

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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