Contents

1 The Making of the 5-HT2C Receptor 1

Jose M. Palacios, Angel Pazos, and Daniel Hoyer

2 Serotonin 5-HT2C Receptors: Chemical Neuronatomy in the Mammalian Brain 17

Guadalupe Mengod

3 The Medicinal Chemistry of 5-HT2C Receptor Ligands 29

Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Francesco Berardi, and Roberto Perrone

4 Insights into 5-HT2C Receptor Function Gained from Transgenic Mouse Models 51

Stephen J. Bonasera

5 Serotonin 5-HT2C Receptor Signal Transduction 75

Maria N. Garnovskaya and John R. Raymond

6 Homology Modeling of 5-HT2C Receptors 97

Nicolas Renault, Amaury Farce, and Philippe Chavatte

7 5-HT2C Receptor Dimerization 129

Katharine Herrick-Davis and Dinah T. Farrington

8 RNA Editing of 5-HT2C Receptor and Neuropsychiatric Diseases 157

Kazuya Iwamoto, Miki Bundo, and Tadafumi Kato

9 Serotonergic Control of Adult Neurogenesis:

Focus on 5-HT2C Receptors 169

Annie Daszuta

10 The Constitutive Activity of 5-HT2C Receptors as an Additional Modality of Interaction of the Serotonergic System 187

Sylvia Navailles and Philippe De Deurwaerdère

11 The 5-HT2C Receptor Subtype Controls Central Dopaminergic Systems: Evidence from

Electrophysiological and Neurochemical Studies 215

Giuseppe Di Giovanni, Ennio Esposito, and Vincenzo Di Matteo

12 The Role of 5-HT2C Receptors in the Pathophysiology and Treatment of Depression 249

Eliyahu Dremencov, Joost H.A. Folgering, Sandra Hogg, Laurence Tecott, and Thomas I.F.H. Cremers

13 5-HT2C Receptors and Suicidal Behavior 261

Fabio Panariello, Naima Javaid, and Vincenzo De Luca

14 The 5-HT2C Receptor as a Target for Schizophrenia 275

Herbert Y. Meltzer, Liwen Sun, and Hitoshi Hashimoto

15 Serotonin and Reward-Related Behavior:

Focus on 5-HT2C Receptors 293

Paul J. Fletcher and Guy A. Higgins

16 Tat-3L4F: A Novel Peptide for Treating Drug Addiction by Disrupting Interaction Between

PTEN and 5-HT2C Receptor 325

Amy Hu, Lintao Jia, Jean-Christian Maillet, and Xia Zhang

17 The Role of Serotonin in Eating Behavior:

Focus on 5-HT2C Receptors 339

Jason C.G. Halford

18 Physiological and Pathophysiological Aspects of 5-HT2c Receptors in Basal Ganglia 351

Philippe De Deurwaerdère, Laurence Mignon, and Marie-Françoise Chesselet

19 Modeling Tardive Dyskinesia: Predictive

5-HT2C Receptor Antagonist Treatment 383

Richard M. Kostrzewa

20 The Role of 5-HT2A/2C Receptors in Sleep and Waking 393

Jaime M. Monti and Héctor Jantos

21 Role of Alternative Splicing of the 5-HT2C

Receptor in the Prader-Willi Syndrome 413

Shivendra Kishore and Stefan Stamm

22 The Role of 5-HT2C Receptor in Epilepsy 429

Rita Jakus and Gyorgy Bagdy

23 The Role of Serotonin on Attentional Processes and Executive Functioning: Focus on 5-HT2C Receptors 445

Eleftheria Tsaltas and Vasileios Boulougouris

24 5-HT2C Receptors in Learning 461

López-Vázquez Miguel Ángel, Gutiérrez-Guzmán Blanca Érika, Cervantes Miguel, and Olvera-Cortés María Esther

25 The Role of 5-HT2C Polymorphisms in Behavioral and Psychological Symptoms of Alzheimer Disease 509

Antonia Pritchard

26 Ocular Hypotension: Involvement of Serotonergic 5-HT2 Receptors 523

Najam A. Sharif

Index 545

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