DA RSS 5HT RSS and VCMs in the Haloperidol Withdrawal Phase

6-OHDA-lesioned rats were tested during the haloperidol-withdrawal phase at intervals, with a series of agonists or antagonists for multiple neurotransmitter systems. The persistent high level of VCMs was not attenuated by a DA D1 antagonist, DA D2 antagonist, alpha-adrenoceptor antagonist, beta-adrenoceptor antagonist, NMDA antagonist, opioid mu antagonist, muscarinic antagonist, GABAA antagonist, adenosine A2A antagonist, or H/5-HT antagonist. Similarly, a 5-HT1A agonist and 5-HT2A antagonist failed to alter VCM number. However, on testing and retesting, several different 5-HT2 antagonists attenuated VCM number. Because at least two of the 5-HT2 antagonists (i.e., mesulergine, miansering) have preferential 5-HT2C antagonist activity, we believe the effectiveness of the 5-HT2 antagonists relates to their ability to block 5-HT2C receptors (Kostrzewa et al. 2007).

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Defeat Drugs and Live Free

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