Dopamine Systems and TD

Conventional antipsychotics are dopamine (DA) D2 receptor antagonists. All dopaminergic tracts in brain are affected, but it appears that the nigrostriatal tract is most intimately associated with TD, since this tract exerts fine motor control. At an effective dose of antipsychotic, ~70-80% of the D2 receptors are blocked. The acute effect of D2 receptor block does not produce TD, but prolonged D2 block can result in TD - hence the term tardive dyskinesia (i.e., delayed induction of a dyskinesia).

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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