Early Research into the Role of Endogenous 5HT in Appetite Regulation

Fenfluramine appeared to be equally as effective as amphetamine and lacked its side-effect profile and abuse potential. It was also a serotonin (5-hydroxytryptam-ine or 5-HT)-acting drug. It was the combination of this drugs specific pharmacological and behavioral properties that triggered much of the early research into the role of endogenous 5-HT in appetite regulation. In 1997, all forms of fenfluramine

Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Liverpool, UK, L69 7ZA e-mail: [email protected]

G. Di Giovanni et al. (eds.), 5-HT2C Receptors in the Pathophysiology of CNS Disease, The Receptors 22, DOI 10.1007/978-1-60761-941-3_17, © Springer Science + Business Media, LLC 2011

were withdrawn from the global market due to serious side-effect issues of valvular heart disease and pulmonary hypertension (Abeniam et al. 1996) an effect associated with peripheral 5-HT2B receptors. However, this withdrawal coincided with the introduction of sibutramine, a noradrenergic and serotonergic reuptake inhibitor, for the treatment of obesity.

The monoamine neurotransmitter serotonin has been intimately linked with appetite expression of over 40 years. Moreover, serotonin-acting drugs constitute the first class of appetite suppressing drugs to clearly modulate human appetite expression without contaminant behavioral effects or abuse potential. For no other peripheral or central target does the wealth of data on the effects of drugs on human appetite exist (Halford et al. 2007). These extensive behavioral data demonstrate that the endogenous hypothalamic serotonin plays an important part in within-meal satiation and postmeal satiety processes. Selectively targeting 5-HT receptors particularly involved in appetite control provides still provides an opportunity for the development of safe, tolerable, and more effective antiobesity agents (Halford et al. 2007).

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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