The next endeavor was to examine if Tat-3L4F interfering peptide could suppress the rewarding effects of abused drugs that lead to addiction. Marijuana is one of many abused drugs that induce gratifying effects by enhancing dopamine levels in the NAc after stimulating VTA dopamine neurons (Zangen et al. 2006). With the in vivo recording of the activity of VTA dopamine neurons again, we observed that when D9-tetrahydrocannabinol (THC), the major psychoactive ingredient of marijuana, was systemically injected alone, dopamine neuronal activity significantly increased as expected (Ji et al. 2006). However, when THC and Tat-3L4F were systemically administered together, the firing rate of VTA dopamine neurons was significantly suppressed, resembling injection by the 5-HT2C agonist R0600175, and reversed by the 5-HT2C antagonist SB 242084 (Ji et al2.C2006). These results imply that Tat-3L4f interfering peptide may be able to block the rewarding effects of marijuana.
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Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.