In rats lesioned as neonates with 6-OHDA and lesioned again in adulthood with the serotoninergic toxin 5,7-DHT, there was an inordinate increase in hyperlocomotor activity. This combined treatment in rats was proposed to model attention deficit hyperactivity disorder (Kostrzewa et al. 1994, 2008b). Moreover, the hyperlocomotor activity was abated by 5-HT2 receptor antagonists (Nowak et al. 2007; Brus et al. 2004). 5-HT systems are also proposed as an alternate phenotypic system beneficially preserving function in Parkinson disease (Kostrzewa and Moratalla, submitted)).
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Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.