HT2C Receptor Subtypes

The 5-HT2C receptor was originally classified as a member of the 5-HT1 family (5-HT1C) (Pazos et al. 1987) but has been reclassified following more extensive investigation of its structure and function (Humphrey et al. 1993). Unlike the 5-HT2A receptors, 5-HT2C receptors are only found within the central nervous system (Palacios et al. 1990). However, 5-HT2C receptors are widely distributed within the brain, and high levels are found in the cortex, limbic system, and basal ganglia. The majority of studies point to a predominantly postsynaptic location for 5-HT2C

receptors, but 5-HT2C receptor mRNA has been localized within the DRN, indicating that this receptor could be found at presynaptic sites as well.

In common with the 5-HT2A receptor, activation of the 5-HT2C receptor also appears to depolarize the cell membrane (Rick et al. 1995; Sheldon and Aghajanian 1991), although as with the majority of data regarding the 5-HT2A receptor, much has been inferred through observations that 5-HT-induced increases in activity are not blocked by a range of other 5-HT-receptor specific antagonists. Hopefully, the fact that there is now a commercially available 5-HT2C receptor agonist, WAY 161503, will enable clarification of both the physiological and behavioral effects of 5-HT2C receptor stimulation.

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Defeat Drugs and Live Free

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