HT2C Receptors and Epilepsy 2241 Localization and Functions

Several neurons involved in excitatory and inhibitory neurotransmission, like GABA-ergic or glutamaterg neuronal cells, express 5-HT2C receptors. Thus, 5-HT2C receptors regulate the activity of neuronal networks involved either in epileptogen-esis or in propagation (Table 22.4). The highest concentration of 5-HT2C receptors is in the choroid plexus, but 5-HT2C binding sites are widely distributed and present in areas of the cortex (olfactory nucleus, pyriform, cingulated, and retrospenial), limbic system (nucleus accumbens, hippocampus, amygdala,), and the basal ganglia (caudate nucleus, substantia nigra). They are present in the pyriform cortex and substantia nigra, demonstrated by 5-HT2C receptor-mediated electrophysiological response in these regions (Sheldon and Aghajanian 1991). Activation of the 5-HT2C receptor increases phospholipase PLC activity in the choroid plexus of various species, but these receptors function also via phospholipase A2 (PLA) and phospholipase D, even more, agonist-independent association with b-arrestins was reported for nonedited and partially edited 5-HT2C receptors (Millan et al. 2008) (Table 22.4).

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Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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