HT2C Receptors and the Cannabinoid Receptors System

The interaction of 5-HT2C receptors with the cannabinoid system through the CB1 receptor has been recently studied (Aso et al. 2009). CBt KO mice exhibited a reduction in the expression of the 5-HT2C receptor in dorsal raphe, nucleus accumbens, and paraventricular nucleus, among other brain areas. In contrast, 5-HT2C receptor expression was higher in the CA3 field of the ventral hippocampus of CB1 KO mice, suggesting different roles of this receptor in these brain areas. The decreased expression of the 5-HT2C receptor in the dorsal raphe of CBt mutant mice could lead to a reduction in the inhibitory effect exerted by the 5-HT2C receptor on 5-HT neurons through the GABAergic mechanism (Boothman et al. 2006), which supports the increased 5-HT extracellular levels in the brain areas receiving projections from the dorsal raphe observed in CBt KO mice. Likewise, the decreased levels of 5-HT2C mRNA in CBt KO mice, observed within the nucleus accumbens and the paraventricular nucleus of the hypothalamus, could indicate a diminished capacity of this receptor to inhibit dopamine activity (Dremencov et al. 2006) and to stimulate corticotrophin-releasing factor release (Heisler et al. 2007), respectively.

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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