HTM and 5HTD Versus 5HT1 and 5HT2 Receptors

With respect to serotonin receptors, it should be remembered that in those days (1983/1984 - this is when we started working together on this subject: José Maria (Chema) Palacios [JMP], Angel Pazos [AP] and Danny Hoyer [DH]), 5-HT receptors were considered to form a fairly simple family, and since the cloning era was to start a few years later, there was little structural evidence for further complexity. In the brain, one could distinguish between 5-HT1 and 5-HT2 sites (Peroutka and Snyder 1979), labeled by [3H]5-HT and [3H]spiper-one/[3H]ketanserin, respectively. In the periphery, 5-HT-M and 5-HT-D receptors had been known for some time (the effects of 5-HT on this receptor were first reported in the guinea-pig ileum), but they were not labeled by anything, primarily since this was the field of physiologists working in the intestine, and electro-physiologists in the peripheral nervous system (Bradley et al. 1986; Gaddum and Picarelli 1957; Hoyer et al. 1994). As it was becoming clear that 5-HT2 sites and 5-HT-D receptors were very closely related (Engel et al. 1984), it was decided to reconsider the whole nomenclature, and there was agreement to name these receptors 5-HTt, 5-HT2 (5-HT-D) and 5-HT3 (5-HT-M): The Bradley scheme was born and the first receptor nomenclature party was in its infancy (Bradley et al. 1986).

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