Humana Press

Editors

Editor-in-Chief Giuseppe Di Giovanni University of Malta Department of Physiology and Biochemistry Msida, Malta

[email protected]

Assistant Editor Vincenzo Di Matteo Consorzio Mario Negri Sud Centro di Ricerche Farmacologiche e Biomediche Chieti, Italy [email protected]

Assistant Editor

Ennio Esposito

Consorzio Mario Negri Sud

Centro di Ricerche

Farmacologiche e Biomediche

Chieti, Italy

[email protected]

ISBN 978-1-60761-940-6 e-ISBN 978-1-60761-941-3

DOI 10.1007/978-1-60761-941-3

Springer New York Dordrecht Heidelberg London

© Springer Science+Business Media, LLC 2011

All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden.

The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.

Printed on acid-free paper

Humana Press is part of Springer Science+Business Media (www.springer.com)

To my wife Samantha,

For her abundant support, for her patience and understanding, and for her love

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