Hypothalamic and Other Areas

Work beginning in the 1980s identified hypothalamic areas such as the paraven-tricular nucleus (PVN) as a primary site where 5-HT acts to suppress feeding (Leibowitz and Alexander 1998). Some evidence indicates that both 5-HT1B and 5-HT2A receptor activation in this site reduces food intake (Currie and Coscina 1997). Recently, Ro60-0175 infused into the PVN induced a moderate reduction in food intake (Lopez-Alonso et al. 2007). Other hypothalamic sites such as the arcuate nucleus have been implicated in mediating the effects of systemically injected 5-HT2C receptor agonists on food intake. A c-Fos mapping study of the effects of VER23799 showed activation not only in expected feeding-related sites such as the PVN but also in the basolateral amygdala (Somerville et al. 2007). Given the suggestion that 5-HT2C receptor agonist-induced reductions in feeding could arise in part through altered functioning of food reward systems, the effects of infusing 5-HT2C receptor agonists into extrahypothalamic sites such as the baso-lateral amygdala, the VTA, or mPFC may be worth examining. The fact that lesions of the PVN do not alter the anorectic effects of TFMPP and d-fenfluramine, which act partly via 5-HT2C receptors, is further evidence that perhaps extrahypo-thalamic sites are in involved in mediating the effects of these types of drugs (Fletcher et al. 1993).

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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