Incidence Persistence Treatment of TD

The overall incidence of TD is ~5% per treatment year (Kane et al. 1982). Thereby, in a population of 100 patients treated with conventional antipsychotics for 3-years, ~15 patients would present with TD. When symptoms of TD initially appear, they can sometimes be suppressed by abruptly elevating the dose of the antipsychotic. However, symptoms of TD can reappear. Typically, TD is long-lived, often irreversible with or without continued treatment with an antipcychotic drug. Unfortunately, there is no recognized treatment for TD.

Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614-1708, USA e-mail: [email protected]

G. Di Giovanni et al. (eds.), 5-HT2C Receptors in the Pathophysiology of CNS Disease, 383 The Receptors 22, DOI 10.1007/978-1-60761-941-3_19, © Springer Science + Business Media, LLC 2011

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