Serotonin receptor 2C (HTR2C) encodes a seven-transmembrane-spanning, G-protein-coupled receptor that activates phospholipase C. Mice deficient for this gene showed a range of behavioral alterations related to neuropsychiatric disorders, including seizure, enhanced exploration of a novel environment, and dysregulation of anxiety-related behaviors (Tecott et al. 1995; Rocha et al. 2002; Heisler et al. 2007). In addition, several studies reported the significant associations between genetic variations of HTR2C and mental disorders such as major depression (MD) and bipolar disorder (BD) (Lerer et al. 2001; Massat et al. 2007). Downregulation of this gene was also reported in postmortem brains of patients with BD and schizophrenia (SZ) (Castensson et al. 2003; Iwamoto et al. 2004). These results implicated the potential importance of this gene in the pathophysiology of neuropsychiatric disorders. Furthermore, what makes this gene a unique candidate is the fact that pre-mRNA of this gene undergoes adenosine-to-inosine (A-to-I) RNA editing by adenosine deaminases (Burns et al. 1997).

Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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