Serotonin receptor 2C (HTR2C) encodes a seven-transmembrane-spanning, G-protein-coupled receptor that activates phospholipase C. Mice deficient for this gene showed a range of behavioral alterations related to neuropsychiatric disorders, including seizure, enhanced exploration of a novel environment, and dysregulation of anxiety-related behaviors (Tecott et al. 1995; Rocha et al. 2002; Heisler et al. 2007). In addition, several studies reported the significant associations between genetic variations of HTR2C and mental disorders such as major depression (MD) and bipolar disorder (BD) (Lerer et al. 2001; Massat et al. 2007). Downregulation of this gene was also reported in postmortem brains of patients with BD and schizophrenia (SZ) (Castensson et al. 2003; Iwamoto et al. 2004). These results implicated the potential importance of this gene in the pathophysiology of neuropsychiatric disorders. Furthermore, what makes this gene a unique candidate is the fact that pre-mRNA of this gene undergoes adenosine-to-inosine (A-to-I) RNA editing by adenosine deaminases (Burns et al. 1997).

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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