Major depression is a severe disorder that affects, at least once in lifetime, 10-20% of world population (Kaplan and Sadock 1995; World Health Organization 2002). The keys of the disease are depressed mood and anhedonia. However, depression is also characterized also by various and significant affective, cognitive, and physical disturbances, such as anxiety, fatigue, impaired memory and concentration difficulties, sleep disturbances, chronic pain, and sexual dysfunctions (Kaplan and Sadock 1995; DSM-IV 2000). Depression is currently considered the fourth major cause of disability worldwide and estimated to become the second cause of disability by 2020 (World Health Organization report 2002). Several different neurotransmitters and their receptors are involved in the pathophysiology of this disease, which is still poorly understood. The current chapter focuses on the role of serotonin-2C (5-HT2C) receptors in the pathophysiology and treatment of depression.

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