Is There a Link Between HBII52 Expression and Hunger Control

A molecular link between a defect in the 5-HT2C production and PWS is an attractive hypothesis, as the 5-HT2C receptor plays a crucial role in hunger control and satiety, which is the major problem in PWS. Since HBII-52 promotes the generation of the most active receptor, it acts like a "genetic agonist" of the serotonin receptor. The administration of selective 5-HT2CR agonists, such as d-fenfluramine has a strong appetite-suppressing effect (Vickers et al. 2001). Underlining the importance of the 5-HT2C receptor for hunger control, the mouse knockout of 5-HT2CR is hyperphagic and develops obesity. Expression of the 5-HT2CR in the arcuate nucleus, a major hunger control center reverses the hyperphagic phenotype (Xu et al. 2008). As mentioned above, when a mutant of the receptor that represents the fully edited 5-HT2CR is expressed in knockout mice, the resulting mice remain hyperphagic (Kawahara et al. 2008; Morabito et al. 2010). Collectively, the data strongly support a model where the loss of HBII-52 causes a loss of the mRNA isoform that encodes the most active form of the receptor, which is necessary for proper hunger control.

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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