Looking for a Physiological Role for 5HT Receptors in the Choroid Plexus

The enormous concentration of 5-HT1C receptors in the choroid plexus of all the species investigated was calling for an examination of the role of these receptors in controlling one of the functions of this tissue, namely, the volume and composition of cerebrospinal fluid. Monique Rigo cannulated rat cerebral ventricles, examined using perfusion with artificial CSF, and radiolabeled inulin alterations in the volume of CSF. We found effects of 5-HT and other drugs, but the system was too complex to carry out detailed pharmacological studies, and we did not progress enough as to get publishable data. Along the same lines in 1988, Lindvall-Axelsson and colleagues (Lindvall-Axelsson et al. 1988) from the University of Lund in Sweden published a detailed study in the rabbit, a better suited model, described the inhibition of CSF production by 5-HT and its blockade by ketanserin.

The role of 5-HT1C (now 5-HT2C) receptors in choroid plexus function has been the object of intense research, even in outer space. In the NASA Website, one can find a description of experiments proposed by Dr. J. Gabrion (Université Pierre et Marie Curie, Paris, France) aimed at studying the role of several molecules including 5-HT2C receptor in choroidal regulation in space/light conditions.

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Defeat Drugs and Live Free

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