The work reviewed in previous sections clearly demonstrates that manipulating 5-HT function via 5-HT2C receptors modulates in a consistent fashion a number of reward-related behaviors, including the behavioral responses to psychoactive drugs such as cocaine and nicotine. All of the work reviewed to date has involved the systemic injection of 5-HT2C receptor ligands, and so the possible sites in the brain where these effects are mediated are not known. Identification of critical brain sites can be achieved by examining the behavioral effects of microinjecting 5-HT2C receptor ligands into discrete brain regions. A small number of studies have begun to do this, focussing on areas of the mesocorticolimbic DA system.
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