Phospholipase D

Native 5-HT2C receptors in choroid plexus epithelial cells also activate phospholipase D (PLD), an enzyme that catalyzes the hydrolysis of phosphatidylcholine to form phosphatidic acid and a released choline head group. 5-HT2C receptor-induced PLD activation involves the G ,, subunit and free Gb subunits, as well as transactivation of a 13 bg 7

the small GTPase RhoA (McGrew et al. 2002). These events are regulated by RNA editing of the 5-HT2C receptor. The RNA-edited isoform of the 5-HT2C receptor, 5-HT2C-vgV has a greatly attenuated ability to functionally couple to Ga13 subunit compared with the nonedited 5-HT2C-INI receptor, and is unable to promote Rho GTPase activity. Indeed, the PLD signal was undetectable in NIH-3 T3 cells heterolo-gously expressing the 5-HT2C-VGV isoform (McGrew et al. 2004).

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

Get My Free Ebook


Post a comment