Postmortem Studies of 5HT2C Function

Decreased messenger ribonucleic acid (mRNA) expression of 5-HT2C receptors has been reported in postmortem prefrontal cortex tissues in 55 patients with schizophrenia and 55 controls (Castensson et al. 2003). Castensson et al. (2005) reported that the decrease in expression of the 5-HT2C receptor was not related to drug action and might be a core feature of the illness. Decreased expression of the 5-HT2C receptor has also been reported in bipolar disorder patients (Iwamoto and Kato 2003). Diminished 5-HT2C receptor expression would be expected to facilitate limbic DA release.

Bipolar Disorder Uncovered

Bipolar Disorder Uncovered

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