Posttransductional Changes

As previously mentioned, to believe that the 5-HT1C receptor was greeted with general acceptance is a vast overstatement. The area was complex, new, and rather hotly debated. It actually took years to be acknowledged by the 5-HT "experts": A famous 5-HT researcher at the time suggested that we go back to the books, since "there were only two 5-HT receptors (S1 and S2)," as it was well know that "there were only two dopamine receptors (D1 and D2)"; therefore, any additional complexity was considered superfluous. Needless to say, the statements made by eminent experts had also an influence on internal acceptance of the value of that type of research. For them the worst was still to come, and it arrived with the irruption of the molecular biology techniques. In fact, the family of serotonin receptors ended up with 14 children. The cloning of GPCRs, including that of multiple 5-HT receptors, the use of receptor KOs, and the development of selective tools/drugs facilitated the eventual acceptance of these strange binding sites as receptors. However, cloning was only to start only 3-4 years later, a long time in the career of a young scientist. The first member of the 5-HT2 family to be cloned was the 5-HT1C receptor. Due to its trans-ductional and structural characteristics, and according to the agreement of the Serotonin Receptor Nomenclature Committee, the site was then renamed 5-HT2C.

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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