Abramowski D, Rigo M, Duc D, et al (1995) Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera. Neuropharmacology 34:1635-1645.

Agarwal D, Glasel JA (1997) Hormone-defined cell system for studying G-protein coupled receptor agonist-activated growth modulation: delta-opioid and serotonin-5HT2C receptor activation show opposite mitogenic effects. J Cell Physiol 171:61-74.

Aiyar J, Grissmer S, Chandy KG (1993) Full-length and truncated Kv1.3 K+channels are modulated by 5-HT1C receptor activation and independently by PKC. Am J Physiol Cell Physiol 265:C1571-C1578.

Alberts GL, Pregenzer JF, Im WB, et al (1999) Agonist-induced GTPgamma35S binding mediated by human 5-HT(2C) receptors expressed in human embryonic kidney 293 cells. Eur J Pharmacol 383(3):311-319.

Alex KD, Yavanian GJ, McFarlane HG, et al (2005) Modulation of dopamine release by striatal 5-HT2C receptors. Synapse 55:242-251.

Backstrom JR, Chang MS, Chu H, et al (1999) Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD). Neuropsychopharmacology 21:77 S-81 S.

Backstrom JR, Price RD, Reasoner DT, et al (2000) Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses. J Biol Chem 275:23620-23626.

Bagdy G (1996) Role of the hypothalamic paraventricular nucleus in 5-HT1A, 5-HT2A and 5-HT2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses. Behav Brain Res 73:277-280.

Bagdy G, Sved AF, Murphy DL, et al (1992) Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. Eur J Pharmacol 210:285-289.

Becamel C, Figge A, Poliak S, et al (2001) Interaction of serotonin 5-HT2C receptors with PDZ10 of the multi PDZ protein MUPP1. J Biol Chem 276:12974-12982.

Becamel C, Alonso G, Galeotti N (2002) Synaptic multiprotein complexes associated with 5-HT2C receptors: a proteomic approach. EMBO J 21:2332-2342.

Becamel C, Gavarini S, Chanrion B, et al (2004) The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins. J Biol Chem 279:20257-20266.

Berg KA, Clarke WP, Sailstad C, et al (1994) Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems. Mol Pharmacol 46:477-484.

Berg KA, Maayani S, Clarke WP (1996) 5-Hydroxytryptamine2C receptor activation inhibits 5-hydroxytryptamine1B-like receptor function via arachidonic acid metabolism. Mol Pharmacol 50:1017-1023.

Berg KA, Maayani S, Goldfarb J, et al (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Mol Pharmacol 54:94-104.

Berg KA, Cropper JD, Niswender CM, et al (2001) RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity. Br J Pharmacol 134:386-392.

Berg KA, Clarke WP, Cunningham KA, et al (2008) Fine-tuning serotonin 2C receptor function in the brain: molecular and functional implications. Neuropharmacology 55:969-976.

Bockaert J, Claeysen S, Becamel C, et al (2006) Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation. Cell Tissue Res 326:553-572.

Burns CM, Chu H, Rueter SM, et al (1997) Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 387:303-308.

Canton H, Emeson RB, Barker EL, et al (1996) Identification, molecular cloning, and distribution of a short variant of the 5-hydroxytryptamine2C receptor produced by alternative splicing. Mol Pharmacol 50:799-807.

Carr DB, Cooper DC, Ulrich SL, et al (2002) Serotonin receptor activation inhibits sodium current and dendritic excitability in prefrontal cortex via a protein kinase C-dependent mechanism. J Neurosci 22:6846-6855.

Chang M, Zhang L, Tam JP, et al (2000) Dissecting G protein-coupled receptor signaling pathways with membrane-permeable blocking peptides. Endogenous 5-HT2C receptors in choroid plexus epithelial cells. J Biol Chem 275:7021-7029.

Chanrion B, Mannoury la Cour C, Gavarini S, et al (2008) Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction. Mol Pharmacol 73:748-757.

Chen Y, Baez M, Yu L (1994) Functional coupling of the 5-HT2C serotonin receptor to G proteins in Xenopus oocytes. Neurosci Lett 179:100-102.

Chen CX, Cho DS, Wang Q, et al (2000) A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA 6:755-767.

Conn PJ, Sanders-Bush E, Hoffman BJ, et al (1986) A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. Proc Natl Acad Sci USA 83:4086-4088.

Cussac D, Newman-Tancredi A, Duqueyroix D, et al (2002) Differential activation of Gq/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking. Mol Pharmacol 62:578-589.

Day M, Olson PA, Platzer J, et al (2002) Stimulation of 5-HT2 receptors in prefrontal pyramidal neurons inhibits Cav1.2 L-Type Ca2+ currents via a PLCbeta/IP3/Calcineurin signaling cascade. J Neurophysiol 87:2490-2504.

De Deurwaerdere P, Navailles S, Berg KA, et al (2004) Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J Neurosci 24:3235-3241.

DiMagno L, Dascal N, Davidson N, et al (1996) Serotonin and protein kinase C modulation of a rat brain inwardly rectifying K + channel expressed in Xenopus oocytes. Pflugers Arch/Eur J Physiol 431:335-340.

Eriksson KS, Stevens DR, Haas HL (2001) Serotonin excites tuberomammillary neurons by activation of Na+/Ca2 + -exchange. Neuropharmacology 40:345-351.

Felder CC, Kanterman RY, Ma AL, et al (1990) Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis. Proc Natl Acad Sci USA 87:2187-2191.

Fitzgerald LW, Iyer G, Conklin, et al (1999) Messenger RNA editing of the human serotonin 5-HT2C receptor. Neuropsychopharmacology 21:82S-90S.

Fitzgerald LW, Burn TC, Brown BS, et al (2000) Possible role of valvular serotonin 5-HT2B receptors in the cardiopathy associated with fenfluramine. Mol Pharmacol 57:75-81.

Flomen R, Knight J, Sham P, et al (2004) Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene. Nucleic Acids Res 32:2113-2122.

Foguet M, Nguyen H, Le H, et al (1992) Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes. Neuroreport 3:345-348.

Gavarini S, Becamel C, Altier C (2006) Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability. Mol Biol Cell 17:4619-4631.

Gohla A, Offermanns S, Wilkie TM, et al (1999) Differential involvement of Galpha 12 and Galpha 13 in receptor-mediated stress fiber formation. J Biol Chem 274:17901-17907.

Gurevich I, Tamir H, Arango V, et al (2002) Altered editing of serotonin 2C receptor premRNA in the prefrontal cortex of depressed suicide victims. Neuron 34:349-356.

Hartman JL IV, Northup JK (1996) Functional reconstitution in situ of 5-hydroxytryptamine2C (5HT2C) receptors with alpha q and inverse agonism of 5HT2C receptor antagonists. J Biol Chem 271:22591-22597.

Heisler LK, Chu HM, Tecott LH (1998) Epilepsy and obesity in serotonin 5-HT2C receptor mutant mice. Ann NY Acad Sci 861:74-78.

Heisler LH, Cowley MA, Tecott LH, et al (2002) Activation of central melanocortin pathways by fenfluramine. Science 297:609-611.

Herrick-Davis K, Grinde E, Niswender CM (1999) Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction. J Neurochem 73:1711-1717.

Herrick-Davis K, Grinde E, Mazurkiewicz JE (2004) Biochemical and biophysical characterization of serotonin 5-HT2C receptor homodimers on the plasma membrane of living cells. Biochemistry 43:13963-13971.

Herrick-Davis K, Grinde E, Harrigan TJ, et al (2005) Inhibition of serotonin 5-hydroxytryptam-ine2C receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein. J Biol Chem 280:40144-40151.

Hoger JH, Walter AE, Vance D, et al (1991) Modulation of a cloned mouse brain potassium channel. Neuron 6:227-236.

Hoyer D, Clarke DE, Fozard JR, et al (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46:157-203.

Huidobro-Toro JP, Valenzuela CF, Harris RA (1996) Modulation of GABA (A) receptor function by G protein-coupled 5-HT2C receptors. Neuropharmacology 35:1355-1363.

Hung BC, Loo DD, Wright EM (1993) Regulation of mouse choroid plexus apical Cl- and K+channels by serotonin. Brain Res 617:285-295.

Ji SP, Zhang Y, Van Cleemput J, et al (2006) Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Nat Med 12:324-329.

Julius D, MacDermott AB, Axel R, et al (1988) Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science 241:558-564.

Julius D, Livelli TJ, Jessell TM, et al (1989) Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science 244:1057-1062.

Kahan C, Julius D, Pouyssegur J, et al (1992) Effects of 5-HT1C-receptor expression on cell proliferation control in hamster fibroblasts: serotonin fails to induce a transformed phenotype. Exp Cell Res 200:523-527.

Kaufman MJ, Hirata F (1996) Cyclic GMP inhibits phosphoinositide turnover in choroid plexus: evidence for interactions between second messengers concurrently triggered by 5-HT2C receptors. Neurosci Lett 206:153-156.

Kaufman MJ, Hartig PR, Hoffman BJ (1995) Serotonin 5-HT2C receptor stimulates cyclic GMP formation in choroid plexus. J Neurochem 64:199-205.

Kenakin T (1995) Agonist-receptor efficacy II: agonist trafficking of receptor signals. Trends Pharmacol Sci 16:232-238.

Knauer CS, Campbell JE, Chio CL, et al (2009) Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors. Naunyn Schmiedeberg's Arch Pharmacol 379:461-471.

Labasque M, Reiter E, Becamel C, et al (2008) Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling. Mol Biol Cell 19:4640-4650.

Leysen JE (2004) 5-HT2 receptors. Curr Drug Targets: CNS Neurol Disord 3:11-26.

Lubbert H, Hoffman BJ, Snutch TP, et al (1987) cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes. Proc Natl Acad Sci USA 84:4332-4336.

Lucaites VL, Nelson DL, Wainscott DB, et al (1996) Receptor subtype and density determine the coupling repertoire of the 5-HT2 receptor subfamily. Life Sci 59:1081-1095.

Mancia F, Assur Z, Herman AG, et al (2008) Ligand sensitivity in dimeric associations of the serotonin 5HT2C receptor. EMBO Rep 9:363-369.

Marcoli M, Maura G, Tortarolo M, et al (1997) Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in rat cerebellum: involvement of 5-hydroxytryptamine2C receptors. J Neurochem 69:427-430.

Marion S, Weiner DM, Caron MG (2004) RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2C receptor isoforms. J Biol Chem 279:2945-2954.

Marion S, Oakley RH, Kim KM, et al (2006) A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. J Biol Chem 281:2932-2938.

Maura G, Marcoli M, Pepicelli O, et al (2000) Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in human neocortex slices: involvement of 5-HT2C and 5-HT1A receptors. Br J Pharmacol 130:1853-1858.

Mayer SE, Sanders-Bush E (1994) 5-Hydroxytryptamine type 2A and 2C receptors linked to Na+/ K+/Cl- cotransport. Mol Pharmacol 45:991-996.

McGrew L, Chang MS, Sanders-Bush E (2002) Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive G betagamma subunits. Mol Pharmacol 62:1339-1343.

McGrew L, Price RD, Hackler E, et al (2004) RNA editing of the human serotonin 5-HT2C receptor disrupts transactivation of the small G-protein RhoA. Mol Pharmacol 65:252-256.

Mengod G, Nguyen H, Le H, et al (1990) The distribution and cellular localization of the serotonin 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution. Neuroscience 35:577-591.

Milatovich A, Hsieh CL, Bonaminio G, et al (1992) Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4). Hum Mol Genet 1:681-684.

Millan MJ (2005) Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie 60:441-460.

Millan MJ, Dekeyne A, Gobert A (1998) Serotonin (5-HT)2C receptors tonically inhibit dop-amine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo. Neuropharmacology 37:953-955.

Millan MJ, Marin P, Bockaert J, et al (2008) Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions. Trends Pharmacol Sci 29:454-464.

Miller KJ (2005) Serotonin 5-HT2C receptor agonists: potential for the treatment of obesity. Mol Interv 5:282-291.

Niswender CM, Sanders-Bush E, Emeson RB (1998) Identification and characterization of RNA editing events within the 5-HT2C receptor. Ann NY Acad Sci 861:38-48.

Niswender CM, Copeland SC, Herrick-Davis K, et al (1999) RNA editing of the human serotonin 5-hydroxytryptamine2C receptor silences constitutive activity. J Biol Chem 274:9472-9478.

Niswender CM, Herrick-Davis K, Dilley GE, et al (2001) RNA editing of the human serotonin 5-HT2C receptor: alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsychopharmacology 24:478-491.

Nitsch RM, Deng M, Growdon JH, et al (1996) Serotonin 5-HT2A and 5-HT2C receptors stimulate amyloid precursor protein ectodomain secretion. J Biol Chem 271:4188-4194.

Nourry C, Grant SG, Borg JP (2003) PDZ Domain Proteins: Plug and Play! Science's STKE 2003(179):re7.

Palacios JM, Markstein R, Pazos A (1986). Serotonin-1C sites in the choroid plexus are not linked in a stimulatory or inhibitory way to adenylate cyclase. Brain Res 380:151-154.

Panicker MM, Parker I, Miledi R (1991) Receptors of the serotonin 1C subtype expressed from cloned DNA mediate the closing of K+membrane channels encoded by brain mRNA. Proc Natl Acad Sci USA 88:2560-2562.

Pazos A, Cortes R, Palacios JM (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res 346:231-249.

Pérez-León JA, Sarabia G, Miledi R, et al (2004) Distribution of 5-hydroxytriptamine2C receptor mRNA in rat retina. Mol Brain Res 125:140-142.

Qiu J, Xue C, Bosch MA, Murphy JG, et al (2007) Serotonin 5-hydroxytryptamine2C receptor signaling in hypothalamic proopiomelanocortin neurons:role in energy homeostasis in females. Mol Pharmacol 72:885-896.

Quick MW, Simon MI, Davidson N, et al (1994) Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes. J Biol Chem 269:30164-30172.

Raymond JR, Mukhin YV, Gelasco A, et al (2001) Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther 92:179-212.

Raymond JR, Turner JH, Gelasco A, et al (2006) 5-HT receptor signal transduction pathways. In: Roth B, ed. The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, Totowa, NJ: Humana.

Rittenhouse PA, Levy AD, Li Q, et al (1993) Neurons in the hypothalamic paraventricular nucleus mediate the serotonergic stimulation of prolactin secretion via 5-HT1C/2 receptors. Endocrinology 133:661-667.

Roberts MF (1996) Phospholipases: structural and functional motifs for working at an interface. FASEB J 10:1159-1172.

Roth BL, Willins DL, Kristiansen K, et al (1998) 5-Hydroxytryptamine 2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine 2C): where structure meets function. Pharmacol Ther 79:231-257.

Saltzman AG, Morse B, Whitman MM, et al (1991) Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes. Biochem Biophys Res Commun 181:1469-1478.

Sanders-Bush E, Fentress H, Hazelwood L (2003) Serotonin 5-HT2 receptors: molecular and genomic diversity. Mol Interv 3:319-330.

Sodhi MS, Burnet PW, Makoff AJ, et al (2001) RNA editing of the 5-HT2C receptor is reduced in schizophrenia. Mol Psychiatry 6:373-379.

Speake T, Kibble JD, Brown PD (2004) Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying K + conductance in rat choroid plexus epithelial cells. Am J Physiol Cell Physiol 286:C611-C620.

Stam NJ, Vanderheyden P, van Alebeek C, et al (1994) Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor. Eur J Pharmacol 269:339-348.

Tecott LH, Sun LM, Akana SF, et al (1995) Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors. Nature 374:542-546.

Terrillon S, Bouvier M (2004) Roles of G-protein-coupled receptor dimerization. EMBO Rep 5:30-34.

Timpe LC, Fantl WJ (1994) Modulation of a voltage-activated potassium channel by peptide growth factor receptors. J Neurosci 14:1195-1201.

Tohda M, Tohda C, Oda H, et al (1995) Possible involvement of botulinum ADP-ribosyltransferase sensitive low molecular G-protein on 5-hydroxytryptamine (5-HT)-induced inositol phosphates formation in 5-HT2C cDNA transfected cells. Neurosci Lett 190:33-36.

Tohda M, Nomura M, Nomura Y (2006) Molecular pathopharmacology of 5-HT2C receptors and the RNA editing in the brain. J Pharmacol Sci 100:427-432.

Turner JH, Raymond JR (2005) Interaction of Calmodulin with the serotonin 5-hydroxytryptamine2A receptor. J Biol Chem 280:30741-30750.

Ullmer C, Schmuck K, Figge A, et al (1998) Cloning and characterization of MUPP1, a novel PDZ domain protein. FEBS Lett 424:63-68.

Urban JD, Clarke WP, von Zastrow M, et al (2007) Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther 320:1-13.

Werry TD, Gregory KJ, Sexton PM, et al (2005) Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2. J Neurochem 93:1603-1615.

Werry TD, Loiacono R, Sexton PM, et al (2008) RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function. Pharmacol Ther 119:7-23.

Werry TD, Stewart GD, Crouch MF, et al (2008) Pharmacology of 5HT2C receptor-mediated ERK1/2 phosphorylation: agonist-specific activation pathways and the impact of RNA editing. Biochem Pharmacol 76:1276-1287.

Westphal RS, Sanders-Bush E (1996) Differences in agonist-independent and -dependent 5-hydroxytryptamine2C receptor-mediated cell division. Mol Pharmacol 49:474-480.

Xie E, Zhu L, Zhao L, et al (1996) The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant. Genomics 35:551-561.

Yuen EY, Jiang Q, Chen P, et al (2008) Activation of 5-HT2A/C receptors counteracts 5-HT1A Regulation of N-Methyl-D aspartate receptor channels in pyramidal neurons of prefrontal cortex. J Biol Chem 283:17194-17204.

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