Serotonin 5HT Systems and TD 1931 5HT Receptors and VCMs

When the 5-HT2 agonist meta-chlorophenylpiperazine (mCPP) was administered to adult rats that had been lesioned neonatally with 6-OHDA there was enhanced induction of VCMs, such that a 1- to 3-mg/kg dose produced three to four times the number of VCMs observed in intact control rats (Gong et al. 1992). This effect was not replicated by the 5-HT1A agonist 8-OH-DPAT [(±) 8-hydroxydipropylami-notetralin] or by the 5-HTjB agonist CGS-12066B (7-trifluoromethyl-4(4-methyl-1-piperazinyl)-pyrrolo[1,2-alquinoxaline]. Moreover, the mCPP effect was not attenuated by the 5-HT1A/1B antagonist pindolol, by the prodiminate 5-HT2A antagonist ketanserin, or by the 5-HT3 antagonist MDL 72222 (3-tropanyl-3,5-dichlo-robenzoate). However, the 5-HT2 antagonist mianserin did attenuate the mCPP effect (Gong et al. 1992). These findings demonstrated that 5-HT2 receptors also could play a role in the induction of VCMs in rats in which DA innervations of striatum and nucleus was compromised.

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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