Serotonin 5HT Systems and TD 1931 5HT Receptors and VCMs

When the 5-HT2 agonist meta-chlorophenylpiperazine (mCPP) was administered to adult rats that had been lesioned neonatally with 6-OHDA there was enhanced induction of VCMs, such that a 1- to 3-mg/kg dose produced three to four times the number of VCMs observed in intact control rats (Gong et al. 1992). This effect was not replicated by the 5-HT1A agonist 8-OH-DPAT [(±) 8-hydroxydipropylami-notetralin] or by the 5-HTjB agonist CGS-12066B (7-trifluoromethyl-4(4-methyl-1-piperazinyl)-pyrrolo[1,2-alquinoxaline]. Moreover, the mCPP effect was not attenuated by the 5-HT1A/1B antagonist pindolol, by the prodiminate 5-HT2A antagonist ketanserin, or by the 5-HT3 antagonist MDL 72222 (3-tropanyl-3,5-dichlo-robenzoate). However, the 5-HT2 antagonist mianserin did attenuate the mCPP effect (Gong et al. 1992). These findings demonstrated that 5-HT2 receptors also could play a role in the induction of VCMs in rats in which DA innervations of striatum and nucleus was compromised.

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