Serotonin Modulation of DA Neuronal Activity

The first electrophysiological study aimed at investigating the effect of 5-HT on DA electrical activity was performed on neurorochemically identified DA neurons in the SNc (Aghajanian and Bunney 1974). Microiontophoretic application of 5-HT was found to exert only weak inhibitory effects on the firing rate of DA neurons (Aghajanian and Bunney 1974). However, most of the early electrophysiological studies on this subject were carried out recording the electrical activity of neurons indiscriminately, in both the SNc and the SNr, and without using the criteria for the neurochemical identification of the neurons recorded (Dray et al. 1976, 1978; Fibiger and Miller 1977).

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