Serotonin Systems

Virtually all parts of the CNS receive innervation from serotonergic fibers arising from cell bodies of the two main subdivisions of the midbrain serotonergic nuclei, the dorsal raphé (DR) and the median raphé (MR) (Azmitia and Segal 1978; Van der Kooy and Attori 1980; Steinbush 1984; Hervé et al. 1987; Van Bockstaele et al. 1993, 1994; Moukhles et al. 1997). Serotonin-containing cell bodies of the raphé nuclei send projections to dopaminergic cells both in the VTA and the SN and to their terminal fields in the nucleus accumbens, prefrontal cortex, and striatum (Van der Kooy and Attori 1980; Steinbush 1984; Hervé et al. 1987; Van Bockstaele et al. 1993, 1994; Moukhles et al. 1997). Electron microscopy demonstrates the presence of synaptic contacts of [3H]5-HT labeled terminals with both dopaminergic and nondopaminergic dendrites in all subnuclei of the VTA and of the SN pars compacta and reticulata (Kalivas 1993; Hervé et al. 1987; Moukhles et al. 1997).

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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