Summary Localization Studies

In summary, a detailed picture of how and where 5-HT2C receptor agonists and antagonists act in the brain to produce their effects on reward-related behavior is lacking. The available data suggest that the VTA and the mPFC are possible sites of action for the well-described inhibitory effects of systemically injected 5-HT2C receptor agonists on aspects of drug abuse-related behaviors and impulsivity. To fully understand how 5-HT, acting via 5-HT2C receptors, controls these behaviors future experiments need to systematically compare the effects of 5-HT2C receptor ligands microinjected into regions such as the VTA, the mPFC and the nucleus accumbens on behavioral measures such as drug self-administration, reinstatement, feeding and impulse control.

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