The rodent model, in which there was perinatal destruction on the dopaminergic nigrostriatal tract along with administration of a conventional antipsychotic drug (i.e., haloperidol) for 1 year, appears to fulfill the most significant criteria for an animal model of TD - namely, gradual development of perioral dyskinesia, persistence of the dyskinesia after discontinuing the antipsychotic treatment, reproducible changes in D2 receptor number in brain, and failure of D1 and D2 receptor antagonists to attenuate the dyskinesia. However, it is particularly relevant from a therapeutic perspective, that 5-HT2 antagonists, and more specifically presumed 5-HT2C receptor antagonists, attenuate the oral dyskinesia in the model (particularly after antipsychotic treatment withdrawal). The rodent model is viable, and the prospect of 5-HT2C antagonists as treatements for TD is encouraging.
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Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.