The 5HT2C Receptor Couples to Cyclic Guanosine Monophosphate GMP Formation

The 5-HT2C receptor has been shown to trigger the formation of cyclic GMP (cGMP) in porcine choroid plexus tissue slices through a pathway that requires PTX-insensitive G proteins, Ca2+, PLA2, and lipoxygenase activity (Kaufman et al. 1995). Further, an inhibitory effect of cGMP on phosphoinositide turnover in choroid plexux has been demonstrated suggesting a possibility of negative interaction between second messenger pathways concurrently activated by 5-HT2C receptor (Kaufman and Hirata 1996). At the same time, the 5-HT2C receptor has been shown to prevent the nitric oxide (NO)-dependent increase of cGMP elicited by activation of N-methyl-d-aspartate (NMDA) receptors in rat cerebellum (Marcoli et al. 1997) and in human neocortical slices (Maura et al. 2000).

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

Get My Free Ebook

Post a comment