The 5HT2C Receptor Regulates Transport Processes

The 5-HT2C receptor modulates a number of distinct transport processes. The 5-HT2C receptor has been shown to activate an electrogenic Na+/Ca2+ exchanger in histaminergic neurons in the rat hypothalamic tuberomammillary nucleus leading to depolarization of the neurons (Eriksson et al. 2001); whereas the cloned 5-HT2C receptor has been linked to activation of Na+/K+/2Cl- cotransport when transfected into NIH-3 T3 fibroblasts (Mayer and Sanders-Bush 1994). Recombinant 5-HT2C receptors expressed in 3 T3 cells have been shown to increase secretion of amyloid precursor proteins in a PKC- and PLA2-dependent manner (Nitsch et al. 1996).

The 5-HT2C receptors in hypothalamic paraventricular nucleus are involved in the serotonergic stimulation of prolactin secretion (Rittenhouse et al. 1993; Bagdy 1996). In addition, 5-HT2C receptors have been shown to mediate vasopressin secretion (Bagdy et al. 1992) as well as oxytocin, corticosterone, and adrenocorticotropic hormone (ACTH) secretion (Bagdy 1996). At the same time, the 5-HT2C receptor markedly suppressed the neuronal release of dopamine (DA) and nora-drenaline (NA) in the rat frontal cortex without affecting serotonergic transmission (Millan et al. 1998). Furthermore, it has been shown that inhibitory control of the nigrostriatal dopamine system occurs by 5-HT2C receptors localized within the terminal region, the dorsal striatum (Alex et al. 2005). In addition, another group using in vivo intracerebral microdialysis and CHO cells expressing 5-HT2C receptors has demonstrated that constitutive 5-HT2C receptor activity participates in the tonic inhibitory control of DA release in the rat striatum and nucleus accumbens in vivo (De Deurwaerdere et al. 2004). Thus, the 5-HT2C receptor has the unique ability to tonically regulate DA release by combined actions involving the effects of endogenous serotonin and constitutive activity of the receptor, and this ability may provide a functional basis for the fine tuning of central DA neuron function (Berg et al. 2008).

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Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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