The Cloning of 5HT2C Receptor

Since our initial studies, the pharmacological similarity between 5-HT1C and 5-HT2 in terms of pharmacological profile was rather striking for us (Pazos et al. 1984a, b; Hoyer et al. 1985a, b). Eventually these similarities suggested these receptors to be closely linked (Hoyer 1988b); this was indeed the case when both receptors were finally cloned: 5-HT1C receptor was cloned first (Lubbert et al. 1987) although the full length sequence came a bit later (Julius et al. 1988), and almost simultaneously the 5-HT2 receptor was also cloned (Pritchett et al. 1988).

The 5-HT2-receptor family was then extended when the fundus receptor was also cloned, first named 5-HT2F, but then renamed 5-HT2B. Finally, the serotonin receptor nomenclature committee agreed that subtypes existed for 5-HT1 and 5-HT2 receptors (cloning had of course strongly supported these views)(Humphrey et al. 1993). It was then logically decided to allocate 5-HT1C to the 5-HT2 family and 5-HT1C was renamed 5-HT2C, which was least disruptive.

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