The Independence of 5HT1C Sites with Respect to 5HT and 5HTJR

1A 1B

In addition, [3H]OH-DPAT was shown to label a more restricted population of sites in the brain than [3H]5-HT (Pazos and Palacios 1985; Hoyer et al. 1986a). By using [3H]5-HT and [3H]mesulergine as radioligands and 8-OH-DPAT, the beta-blocker (SDZ 21-009, a very useful compound picked by Guenter Engel), and mesulergine itself as the main displacers, we succeeded in identifying anatomical areas particularly enriched in each 5-HT1 subtype: Some examples are the dentate gyrus of the hippocampus for the 5-HT1A, the substantia nigra (reticular) for the 5-HT1B, and of course, the choroid plexus for the "new" 5-HT1C. These studies contributed to establishing the independence of 5-HT1C sites with respect to 5-HT1A and 5-HT1B. 1C

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

Get My Free Ebook


Post a comment