The Multiplicity of Receptors for a Single Neurotransmitter

One concept that raised tremendous opposition in the beginning was the multiplicity of receptors for a single neurotransmitter. It was a generally accepted concept that the number of receptors for a given neurotransmitter was very limited. The concept moved from the extreme - "one transmitter-one receptor" - to the "liberal" - "one transmitter-two receptors." Examples include acetylcholine-nicotinic and muscarinic, noradrenalin-alpha and b-adrenergic receptors, and histamine-^ and histamine-H2. Proposing additional or more than two receptors was viewed as a heresy, and if the proposal was coming from results based on radioligand binding, it was viewed as doubly heretical. In other words, radioli-gand binding was considered to represent a rather obscure side product of biochemical pharmacology, as were the effects of guanine nucleotides on agonist binding (Laduron 1984), which were merely associated with detergent-like effects of the GTP and the likes, rather than on active versus inactive states of the receptor (about 20 years later, the Nobel Prize was attributed for the discovery of G proteins). However, as Galileo said e pur si muove, more and more results were accumulating making it difficult to constrain the size of receptor families.

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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