The Pharmacological Profile of the New 5HT1C Receptor

Subsequently, our work addressed the characterization of the pharmacological profile of the new receptor at the microscopic level, by constructing autoradiographic competition curves. These studies revealed a pharmacological profile fully comparable to the one found in parallel in membranes (see section 1.5). They also showed the first picture of the distribution of this subtype throughout the rat brain. In addition to the choroid plexuses that presented the highest autoradiographic density by far, clearly detectable levels of the new 5-HT sites were mainly localized over the olfactory system, hippocampus (CA1 field), thalamic nuclei, substantia nigra, and spinal cord (external); lower levels were detected in neocortex (piriform, cingulate, frontal), putamen, globus pallidus, hypothalamus (ventromedial), and several nuclei at brainstem (i.e., spinal trigeminal nucleus). In general, our autoradiographic studies illustrated very well the power of adding the anatomical dimension to the binding strategies at that time. In fact, without the initial identification of a region enriched in only one class of receptor site, it would be rather unlikely to go for the detailed studies in choroid plexuses membranes that eventually led to the full description of the renamed 5-HT2C receptors.

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