Professor Norman Ho (University of Utah) was very kind to critically read the Chapter 7 and comment on the various derivations and concepts of permeability. His unique expertise on the topic spans many decades. His thoughts and advice (30 pages of handwritten notes) inspired me to rewrite some of the sections in that chapter. I am very grateful to him. Special thanks go to Per Nielsen and Cynthia Berger of pION for critically reading and commenting on the manuscript. I am grateful to other colleagues at pION who expertly performed many of the measurements of solubility and permeability presented in the book: Chau Du, Jeffrey Ruell, Melissa Strafford, Suzanne Tilton, and Oksana Tsinman. Also, I thank Dmytro Voloboy and Konstantin Tsinman for their help in database, computational, and theoretical matters. The helpful discussion with many colleagues, particularly Manfred Kansy and Holger Fisher at Hoffmann La-Roche, Ed Kerns and Li Di at Wyeth Pharmaceuticals, and those at Sirius Analytical Instruments, especially John Comer and Karl Box, are gratefully acknowledged. Helpful comments from Professors John Dearden (Liverpool John Moores University) and Hugo Kubinyi (Heidelberg University) are greatly appreciated. I also thank Professor Anatoly Belyustin (St. Peterburgh University) for pointing out some very relevant Russian literature. Chris Lipinski (Pfizer) has given me a lot of good advice since 1992 on instrumentation and pharmaceutical research, for which I am grateful. Collaborations with Professors Krisztina Takacs-Novak (Semmelweis University, Budapest) and Per Artursson (Uppsala University) have been very rewarding. James McFarland (Reckon.Dat) and Alanas Petrauskas (Pharma Algorithms) have been my teachers of in silico methods. I am in debt to Professor Joan Abbott and Dr. David Begley for allowing me to spend 3 months in their laboratory at King's College London, where I learned a lot about the blood-brain barrier. Omar at Cafe Minon, Warwick Street in Pimlico, London, was kind to let me spend many hours in his small place, as I wrote several papers and drank a lot of coffee. Lasting thanks go to David Dyrssen and the late Jannik Bjerrum for planting the seeds of most interesting and resilient pH-metric methodologies, and to Professor Bernard Testa of Lausanne University for tirelessly fostering the white light of physicochemical profiling. My congratulations to him on the occasion of his retirement.

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