Figure 7.67 Human intestinal absorption compared to (a) pION's double-sink sum-Pe PAMPA GIT model and (b) human jejunal permeabilities [56].

about two and a half orders for the HJP data. Such a spread in the PAMPA data could facilitate the selection of well-absorbed molecules from those poorly absorbed.

In conclusion, the double-sink sum-Pe PAMPA in vitro GIT assay seems to predict human absorption as well as in vivo human permeability measurements (see Figs. 7.66a,b) and in vitro Caco-2 permeability measurements (see Figs. 7.60 and 7.63), but at a lower cost and higher speed.

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