Hplc Methods

HPLC log P techniques, first described by Mirrlees et al. [374] and Unger et al., [375], are probably the most frequently used methods for determining log P. The directly measured retention parameters are hydrophobicity indices, and need to be converted to a log P scale through the use of standards. The newest variants, breadths of scope, and limitations have been described in the literature [292298]. A commercial automated HPLC system based on an extension of the approach described by Slater et al. [150] has just introduced by Sinus (www.sirius-analytical.com).

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